TNFSF8
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Official Full Name
tumor necrosis factor (ligand) superfamily, member 8 -
Overview
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TNFSF8;tumor necrosis factor (ligand) superfamily, member 8;CD30LG;tumor necrosis factor ligand superfamily member 8;CD153;CD30-L;CD30 ligand;CD153 antigen;CD30 antigen ligand;CD30L;MGC138144
Recombinant Proteins
- Cynomolgus
- Human
- Mouse
- Rat
- Rhesus macaque
- Chicken
- Mus musculus
- HEK293
- E.coli
- Human Cell
- CHO
- Mouse myeloma cell line
- Mammalian cells
- Mammalian Cell
- Insect Cell
- E.coli expression system
- Human Cells
- HEK293T
- His
- Fc
- GST
- Fc&Avi
- Non
- mFc
- Flag
- StrepII
- His&GST
- Myc&DDK
- mIgG2a
- His&Fc&Avi
Involved Pathway
TNFSF8 involved in several pathways and played different roles in them. We selected most pathways TNFSF8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TGFBR1B,CD40,TNFSF18,INHBE,PRL,VEGFB,CXCL16,CCL14,CXCR4,IFNK |
Protein Function
TNFSF8 has several biochemical functions, for example, cytokine activity,receptor binding,tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF8 itself. We selected most functions TNFSF8 had, and list some proteins which have the same functions with TNFSF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | SECTM1,IFNA8,SPAW,IL4,IFNL3,Cxcl15,GPR19,IFNK,IFNE,IL6 |
| receptor binding | DHRS4,WNT5B,AGRP,SRPX2,UCN2,NTF7,PLAUR,TNFSF12,RIPK2,Artn |
| tumor necrosis factor receptor binding | TNFSF14,TRADD,TNFSF15,CASP8,TNFSF12,FASLG,TRIM37,TNF,FADD,TRAF2 |
Interacting Protein
TNFSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF8.
TNFSF8 Related Signal Pathway
Resources
Research Area
Natural Killer (NK) Cell CD AntigenNatural Killer Cell (NK Cell)
Co-stimulatory TNF Superfamily Molecules
CD Antigen (Helper T Cells)
Tumor Necrosis Factor (TNF)
Co-stimulatory Molecules
T Follicular Helper (Tfh) Cells
Related Services
Related Products
References
