TNFSF12
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Official Full Name
tumor necrosis factor (ligand) superfamily, member 12 -
Overview
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. -
Synonyms
TNFSF12;tumor necrosis factor (ligand) superfamily, member 12;APO3L;DR3LG;TWEAK
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- Cynomolgus
- Mus musculus
- E. coli
- E.coli
- C-hFc
- HEK293
- Mammalian Cell
- Human Cell
- Mouse
- E.coli expression system
- HEK293T
- CHO
- N-His
- Flag
- Non
- His
- mFc
- Fc
- GST
- His&Fc
- His&Flag
- His&SUMO
- His&Fc&Avi
- N-rFc
Involved Pathway
TNFSF12 involved in several pathways and played different roles in them. We selected most pathways TNFSF12 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFSF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF11A,CXCR6,TNFSF15,GM13305,IL8L1,CSH,PDGFB,CXCR7,CCL14,GM2506 |
Protein Function
TNFSF12 has several biochemical functions, for example, cytokine activity,protein binding,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFSF12 itself. We selected most functions TNFSF12 had, and list some proteins which have the same functions with TNFSF12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tumor necrosis factor receptor binding | FADD,CD40LG,TNFSF13,LTB,TRADD,TNFB,TNFSF10L3,TNFSF9,TRIM37,TNFSF13B |
| receptor binding | P2RX7,VTCN1,ABCA1,PTK6,FGF24,LAMA2,HFE2,PARK7,GAS6,TMED1 |
| protein binding | LGI1,NAT9,TMEM30B,SCP2,MBNL3,RPS16,TSGA10IP,MAP3K3,MRM1,HSCB |
| cytokine activity | GM13279,BMP7A,IL7,IL36RN,Ccl12,FAM3D,Il1f6,IL17A/F2,SPP1,BMP7 |
Interacting Protein
TNFSF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFSF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFSF12.
TNFSF12 Related Signal Pathway
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References
- Sastre, C; Fernandez-Laso, V; et al. Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:721-734(2014).
- Zhou, H; Hittelman, WN; et al. Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors. CANCER RESEARCH 73:4439-4450(2013).
