NTF3
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Official Full Name
neurotrophin 3 -
Overview
Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene. The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor). -
Synonyms
Ntf3;neurotrophin 3;neurotrophin-3;HDNF;NT-3;NGF-2;neurotrophic factor;nerve growth factor 2;neurotrophin-3 (HDNF/NT-3);NT3;NGF2
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Human/Mouse
- Human
- Mouse
- HEK293
- Mammalian Cell
- E.coli
- Human Cell
- Sf21 Insect Cell
- Insect Cell
- CHO
- Non
- His
- StrepII
- His&Myc
- His&Fc&Avi
- Flag
- N-His&C-Myc
Involved Pathway
NTF3 involved in several pathways and played different roles in them. We selected most pathways NTF3 participated on our site, such as MAPK signaling pathway,Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF22,MAPK8IP2,Fasl,HSPA8,MECOM,GADD45B,MAP2K6,MAP3K11,MAP2K2,FGF21 |
| Neurotrophin signaling pathway | Fasl,SHC3,MAPK13,RAF1,BDNF,KIDINS220,CDC42,RPS6KA3,ZNF274,SHC2 |
Protein Function
NTF3 has several biochemical functions, for example, chemoattractant activity,growth factor activity,neurotrophin p75 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NTF3 itself. We selected most functions NTF3 had, and list some proteins which have the same functions with NTF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | FGF20B,BMP7,AMH,CD320,MACC1,NRG3,BMP15,IL11,PTN,PDGFAB |
| chemoattractant activity | FGF2,SAA2,VEGFC,CCL16,HGF,CCL15,BMP4,FGF10,VEGFA,FGF7 |
| neurotrophin p75 receptor binding | NTRK1,ZFP110,NRADD |
| protein binding | HGD,CDC25A,TAGLN,PRKD2,TOP1,STXBP3A,TCEANC,SSRP1,GNB5,ZNF295 |
| receptor binding | FGG,IL29,ANGPTL2,TRIM24,CD58,HSPA1A,DAO1,IAPP,ZAP70,CADM1 |
Interacting Protein
NTF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTF3.
MEOX2;BDNF;SORCS2
Resources
Research Area
Diabetic Peripheral NeuropathyNeurotrophin/Trk Family
VPS10P-domain Family
Neurotrophin
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References
