Native Human NTF3

Description :	The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
Source :	E. coli
Tissue specificity :	Brain and peripheral tissues.
Form :	Lyophilised
Storage :	Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids :	The active form of NT-3 is a dimer formed by two identical 119 amino acid subunits that is held together by strong hydrophobic interactions:YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNS PVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQ TYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT
Sequence Similarities :	Belongs to the NGF-beta family.
Tag :	Non

Gene Name	NTF3 neurotrophin 3 [ Homo sapiens ]
Official Symbol	NTF3
Synonyms	NTF3; neurotrophin 3; neurotrophin-3; NGF2;
Gene ID	4908
mRNA Refseq	NM_001102654
Protein Refseq	NP_001096124
MIM	162660
Uniprot ID	P20783
Chromosome Location	12p13
Pathway	MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem; Neurotrophin signaling pathway, organism-specific biosystem; Neurotrophin signaling pathway, conserved biosystem;
Function	growth factor activity; nerve growth factor binding; neurotrophin receptor binding; receptor binding;