Active Recombinant Human Neurotrophin 3
| Cat.No. : | NTF3-044H |
| Product Overview : | Recombinant human NT-3 was expressed in E. coli and purified by SDS PAGE and HPLC, 13.6 KDa. |
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| Cat. No. : | NTF3-044H |
| Description : | NT-3 is a neurotrophic factor structurally related to beta-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, Mouse and rat NT-3 are identical. |
| Source : | Human |
| Host : | E.coli |
| Form : | Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Allow to set for at least 30 minutes, mix well. |
| Purity : | > 98% pure by SDS PAGE and HPLC |
| Sequence : | Region of NT3 protein corresponding to amino acids MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT. |
| Molecular Mass : | 13.6 kDa |
| Applications : | Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions |
| Endotoxin Levels : | Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
| Bioactivity : | The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml. |
| Storage : | Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
| Tag : | Non |
| Gene Name | NTF3 neurotrophin 3 [ Homo sapiens ] |
| Official Symbol | NTF3 |
| Synonyms | neurotrophin 3; NT3; HDNF; NGF2; NGF-2; MGC129711; NTF3; NT-3; Nerve growth factor 2; Neurotrophic factor |
| Gene ID | 4908 |
| mRNA Refseq | NM_001102654 |
| Protein Refseq | NP_001096124 |
| MIM | 162660 |
| UniProt ID | P20783 |
| Chromosome Location | 12p13 |
| Pathway | MAPK signaling pathway; Neurotrophic factor-mediated Trk receptor signaling; Neurotrophin signaling pathway; Trk receptor signaling mediated by the MAPK pathway; p75(NTR)-mediated signaling |
| Function | growth factor activity; nerve growth factor binding; neurotrophin receptor binding; receptor binding |
Not For Human Consumption!
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