NRG1
-
Official Full Name
neuregulin 1 -
Overview
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009] -
Synonyms
NRG1;neuregulin 1;GGF;HGL;HRG;NDF;ARIA;GGF2;HRG1;HRGA;SMDF;MST131;pro-neuregulin-1, membrane-bound isoform;MSTP131;pro-NRG1;glial growth factor;neu differentiation factor;neuregulin 1 type IV beta 3;neuregulin 1 type IV beta 1a;sensory and motor neuron derived factor;heregulin, alpha (45kD, ERBB2 p185-activator)
Recombinant Proteins
- Human
- Canine
- Rat
- Zebrafish
- Chicken
- Mouse
- E.coli
- HEK293
- Insect Cells
- Human Cells
- Sf21 Cells
- Hordeum Vulgare
- Mammalian Cells
- CHO
- His
- Fc
- Non
- mFc
- HQ
- Fc&His
- Flag
- GST&His
- Avi&Fc&His
Involved Pathway
NRG1 involved in several pathways and played different roles in them. We selected most pathways NRG1 participated on our site, such as ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | PIK3CG,PAK2B,ERBB4,PAK6,ERBB3,RAF1,HRASA,CAMK2G,CAMK2D,CAMK2B1 |
Protein Function
NRG1 has several biochemical functions, for example, ErbB-2 class receptor binding,ErbB-3 class receptor binding,chemorepellent activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NRG1 itself. We selected most functions NRG1 had, and list some proteins which have the same functions with NRG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor tyrosine kinase binding | PCNA,DNAJA3,HYAL2,TP53,CPNE3,PTPN1,NRG3,FLT3LG,ARHGEF16,ZNF259 |
| chemorepellent activity | EPHA7,SEMA6D,SEMA4BA,SEMA3FA,SEMA4E,SEMA4C,SEMA6B,SEMA3B,SEMA3G,SEMA3GA |
| protein tyrosine kinase activator activity | ABI1A,ABI3A,Cd24a,AFAP1L2,CD24,ERBB3,ERCC6,PAK2,ABI1,GAS6 |
| cytokine activity | IL1RN,TGFB2,IL13,IL17A/F1,ADIPOQ,GDF10B,TNFSF12,IFNG,IFNA16,CMTM8 |
| protein binding | ABL2,NCKIPSD,AHSA2,TMEM147,SGOL1,TYROBP,SERPINC1,NSMCE4A,TFAP2B,LOX |
| receptor binding | TNFSF13,LGI1,DDX54,UFD1L,HFE2,LEPROT,EHHADH,RAB8B,NPY,IDUA |
| transmembrane receptor protein tyrosine kinase activator activity | EFNA5,GREM1,EGF,ANGPT4,NRG3 |
| growth factor activity | LIF,BMP6,NTF3,FGF3,WISP3,FGF10B,EREG,ENDOU,GDF10,IL7 |
| ErbB-3 class receptor binding | ERBB2,PIK3R1,CDK5 |
Interacting Protein
NRG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRG1.
EGFR;dnaE;q7cgr6_yerpe;CDC5L
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References
- McCormick, ME; Collins, C; et al. Platelet Endothelial Cell Adhesion Molecule-1 Mediates Endothelial-Cardiomyocyte Communication and Regulates Cardiac Function. JOURNAL OF THE AMERICAN HEART ASSOCIATION 4:-(2015).
- Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
