Recombinant Human neuregulin 1 Protein, Flag tagged
Cat.No. : | NRG1-150H |
Product Overview : | Recombinant human NRG1 protein (Q02297-6) (Thr 176-Lys 246) with a Flag tag at the C-terminus was expressed in E. coli. |
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Species : | Human |
Source : | E.coli |
Tag : | Flag |
Protein Length : | 176-246aa |
Description : | Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1. |
Tag : | C-Flag |
Molecular Mass : | 9.9 kDa |
Endotoxin : | Less than 1.0 EU/μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol. |
Reconstitution : | Reconstitute at 250 μg/mL in sterile water. |
Gene Name | NRG1 neuregulin 1 [ Homo sapiens (human) ] |
Official Symbol | NRG1 |
Synonyms | NRG1; neuregulin 1; HGL; pro-neuregulin-1, membrane-bound isoform; GGF; HRG; NDF; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator); ARIA; GGF2; HRG1; HRGA; SMDF; MST131; |
Gene ID | 3084 |
mRNA Refseq | NM_001159995 |
Protein Refseq | NP_001153467 |
MIM | 142445 |
UniProt ID | Q02297 |
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Not For Human Consumption!
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