Recombinant Human neuregulin 1 Protein, Tag Free

Cat.No. : NRG1-166H
Product Overview : Recombinant human NRG1 protein (Q02297-6) (Ser 20-Lys 246) without tag was expressed in HEK293.
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Species : Human
Source : HEK293
Tag : Non
Protein Length : 20-246aa
Description : Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1.
Tag : Non
Molecular Mass : 25.2 kDa
Endotoxin : Less than 1.0 EU/μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
Reconstitution : Reconstitute at 250 μg/mL in sterile water.
Gene Name NRG1 neuregulin 1 [ Homo sapiens (human) ]
Official Symbol NRG1
Synonyms NRG1; neuregulin 1; HGL; pro-neuregulin-1, membrane-bound isoform; GGF; HRG; NDF; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator); ARIA; GGF2; HRG1; HRGA; SMDF; MST131;
Gene ID 3084
mRNA Refseq NM_001159995
Protein Refseq NP_001153467
MIM 142445
UniProt ID Q02297

Not For Human Consumption!

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