MIF
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Official Full Name
macrophage migration inhibitory factor (glycosylation-inhibiting factor) -
Overview
MIF is a proinflammatory cytokine involved in many inflammatory reactions and disorders. MIF (macrophage migration inhibitory factor) was one of the first cytokines to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity. MIF is involved in both autoimmune disorders and tumorigenesis. -
Synonyms
MIF;macrophage migration inhibitory factor (glycosylation-inhibiting factor);GIF;GLIF;MMIF;Macrophage migration inhibitory factor;EC=5.3.2.1;Glycosylation-inhibiting factor;L-dopachrome isomerase;L-dopachrome tautomerase;EC=5.3.3.12;Phenylpyruvate tautomerase;OTTHUMP00000198465
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Cynomolgus
- E.coli
- HEK293
- Hi-5 Insect Cells
- Mammalian Cells
- Human Cells
- Wheat Germ
- Yeast
- In Vitro Cell Free System
- Non
- His
- Avi&His
- DDK&Myc
- Avi&Fc&His
- His&Myc
- GST
Involved Pathway
MIF involved in several pathways and played different roles in them. We selected most pathways MIF participated on our site, such as Tyrosine metabolism,Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tyrosine metabolism | GSTZ1,COMTA,ALDH3A1,ADH2-1,GOT2,DCT,FAH,COMTB,MAOA,AOX3 |
| Phenylalanine metabolism | MAOB,HPD,ALDH1A3,MAOA,GOT2B,IL4I1,ALDH3B2,GOT2,ALDH3B1,HPDB |
Protein Function
MIF has several biochemical functions, for example, chemoattractant activity,cytokine activity,cytokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MIF itself. We selected most functions MIF had, and list some proteins which have the same functions with MIF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM83A,CNTNAP4,POLDIP2,MLC1,ATG16L1,CFTR,TCF12,SOCS1,MFAP1,SNRPB2 |
| cytokine activity | IL36A,IL15L,Ifna11,NRG1,IL3,HMGB1A,THPO,Il23a; Il12b,IL25,IL22 |
| cytokine receptor binding | IFNA14,IFNPHI1,IFNA12,IL17A,IL15L,IL17A/F1,IFNA8,IFNW1,IL21,IFNPHI4 |
| chemoattractant activity | LGALS3,NTF3,CXCL12B,BMP4,CXCL12,CCL16,HMGB1,FGF2,FGF7,FIGF |
| dopachrome isomerase activity | DCT,DDT |
| receptor binding | GSTM7,ADM,ACOX3,UCN2,P2RX4,HTT,CD58,SCP2,POMC,F2RL1 |
Interacting Protein
MIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MIF here. Most of them are supplied by our site. Hope this information will be useful for your research of MIF.
COPS5;BCL2L11;CFLAR;FIBP;BCL2L11;BCL2L11;EIF1B;EPB41;MPG;HLA-B;VHL;ILK;IKBKE;DSTYK
Resources
Research Area
AdipocytokinesOther Cytokines & Receptors
Inflammatory Mediators
Glomerulonephritis Therapeutic Targets
Rheumatoid arthritis Therapeutic Targets
Related Services
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References
- Wirtz, TH; Tillmann, S; et al. Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. ATHEROSCLEROSIS 239:1-10(2015).
- Zis, O; Zhang, S; et al. Hypoxia Signaling Regulates Macrophage Migration Inhibitory Factor (MIF) Expression in Stroke. MOLECULAR NEUROBIOLOGY 51:155-167(2015).
