Recombinant Human MIF Protein

• Cat.No.: MIF-72H
• Product Overview: Recombinant Human Macrophage migration inhibitory factor is produced by our E.coli expression system and the target gene encoding Met1-Ala115 is expressed.

Specification

• Species: Human
• Source: E.coli
• Description: Human MIF is a 12.5 kDa, 115 amino acid (aa) nonglycosylated polypeptide that is synthesized without asignal sequence .Secretion occurs nonclassically via an ABCA1 transporter.Pro-inflammatory cytokine.Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites ofinflammation suggests a role as mediator in regulating the function of acrophages in host defense.Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase anddopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clearwhether the tautomerase activity has any physiological relevance, and whether it is important for cytokineactivity.
• Form: Supplied as a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4.
• AA Sequence: Met1-Ala115
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Dry Ice/ice packs

Gene Information

• Gene Name: MIF macrophage migration inhibitory factor [ Homo sapiens (human) ]
• Official Symbol: MIF
• Synonyms: Macrophage migration inhibitory factor; MMIF; Glycosylation-inhibiting factor; GLIF; L-dopachrome tautomerase; Phenylpyruvate tautomerase; GIF
• Gene ID: 4282
• mRNA Refseq: NM_002415.2
• Protein Refseq: NP_002406.1
• MIM: 153620
• UniProt ID: P14174