CXCL3
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Official Full Name
chemokine (C-X-C motif) ligand 3 -
Overview
Cytokine-induced neutrophil chemo attractant 1(CINC-1) was originally purified from media conditioned by IL-1βstimulated rat kidney epithelioid cells (NRK-52E). Amino acid sequence that encodes for rat CINC-1 was identified in 1989 by Watanabe's group at Toyama Medical and Pharmaceutical University. CINC-1 is a member of the alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2α, CINC-2β, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2α, CINC-2β, CINC-3/MIP-2. In addition, GROα, GROβ and GROγ is sharing 68%, 71% and 69%, identity with CINC-1. This has been suggested that CINCs are the rat counterpart of human GROs. -
Synonyms
Cxcl3;Cinc2;Cinc-2;Gm1960;chemokine (C-X-C motif) ligand 3;GRO-gamma;SCYB3;GRO-gamma(1-73);GRO3;MIP2-beta;CINC-2b;MIP2B;GROg;MIP-2b;C-X-C motif chemokine 3;GRO3 oncogene;melanoma growth stimulatory activity gamma;Growth-regulated protein gamma;MGSA gamma2;Macrophage inflammatory protein 2-beta;GROG;C-X-C motif chemokine 3;MIP2-alpha/beta;macrophage inflammatory protein 2-alpha/beta;cytokine-induced neutrophil chemoattractant 2;cytokine-induced neutrophil chemoattractant-2
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Cynomolgus
- yeast
- CHO
- E.coli
- Mammalian Cell
- HEK293
- Human Cells
- In Vitro Cell Free System
- Yeast
- Non
- Fc
- His
- MBP
- His&Fc&Avi
- GST
Involved Pathway
CXCL3 involved in several pathways and played different roles in them. We selected most pathways CXCL3 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Salmonella infection | LBP,PFN2L,NLRC4,CCL4L2,PFN4,WASB,CCL3L3,RHOGB,MAPK14B,ROCK2B |
| Legionellosis | IL12B,SAR1B,IL-8,NFKBIA,HSPA2,EEF1A1,BCL2L13,ITGAM,CXCL2,SAR1A |
| Cytokine-cytokine receptor interaction | OSMR,CCL26,TNFSF11,Fasl,KDRL,CSF2RA,CCR6,CXCR4,LTA,CXCL12 |
| Chemokine signaling pathway | RELA,GNG10,CCL11,CCR1,JAK3,GNG11,PIK3CG,CXCL10,GNAI3,CCR6 |
| TNF signaling pathway | PIK3R5,ATF4,IL6,IL18R1,MAPK13,RIPK1,MLKL,CASP7,BIRC2,CCL20 |
Protein Function
CXCL3 has several biochemical functions, for example, CXCR chemokine receptor binding,chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL3 itself. We selected most functions CXCL3 had, and list some proteins which have the same functions with CXCL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine activity | CCL20,CCL19A.1,IL8L2,CXCL13,CXCL14,CCL28,CCL23,CCL19,CXCL2,CX3CL1 |
| CXCR chemokine receptor binding | CXCL2,CXCL5,ITCH,PPBP,CXCL12A,CXCL12B,PF4V1,CXCL6,CXCL1,CXCL20 |
Interacting Protein
CXCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL3.
Resources
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References
- See, ALP; Chong, PK; et al. CXCL3 is a Potential Target for Breast Cancer Metastasis. CURRENT CANCER DRUG TARGETS 14:294-309(2014).
- Girolomoni, G; Mrowietz, U; et al. Psoriasis: rationale for targeting interleukin-17. BRITISH JOURNAL OF DERMATOLOGY 167:717-724(2012).
