CHRM3
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Official Full Name
cholinergic receptor, muscarinic 3 -
Overview
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. -
Synonyms
CHRM3;cholinergic receptor muscarinic 3;CHRM 3;HM3;M3 muscarinic receptor;muscarinic 3;Muscarinic M3 Receptor (a.a. 580-589);Muscarinic M3 Receptor;muscarinic acetylcholine receptor M3;OTTHUMP00000037632
Recombinant Proteins
- Human
- Rat
- Chicken
- Rhesus macaque
- Sus scrofa (Pig)
- Pongo Pygmaeus
- Gorilla gorilla gorilla (Western lowland gorilla)
- Pan troglodytes
- Mus musculus
- Bovine
- Wheat Germ
- Mammalian Cells
- HEK293
- Yeast
- E.coli
- In Vitro Cell Free System
- Non
- GST
- His
- Avi
- Fc
- Flag
- B2M
Involved Pathway
CHRM3 involved in several pathways and played different roles in them. We selected most pathways CHRM3 participated on our site, such as Acetylcholine regulates insulin secretion,Amine ligand-binding receptors,Calcium Regulation in the Cardiac Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHRM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acetylcholine regulates insulin secretion | MARCKSA,MARCKSB |
| Cholinergic synapse | KCNQ1,KCNQ2,CHRM4,AKR1C1,CHRM2,CAMK2D,GNAO1,CREB5,KCNQ3,CHRNB2 |
| GPCR downstream signaling | CXCR7B,LPAR5A,UTS2,ARHGEF17,ABHD6B,CCR3,RAMP2,TAS2R7,SSTR5,HRH3 |
| Class A/1 (Rhodopsin-like receptors) | RLN3A,OXGR1A.2,CX3CR1,GPR4,KEL,OXTRL,SST,CCR5,GPR132B,QRFPR |
| G alpha (q) signalling events | OPN4,GPR4,LPAR1,ARHGEF25,RGS18,EDN2,LPAR2A,FPR-RS6,AGT,KALRNB |
| Calcium Regulation in the Cardiac Cell | RGS19,RGS7,CCDC102A,RGS17,FKBP1A,CHRM4,CHRM2,CX44.1,RGS4,GJA3 |
| Amine ligand-binding receptors | HRH3,DRD5,CHRM4,DRD3,ADRA2C,ADRA2B,CHRM5,ADRA1B,ADRA2A,ADRB2 |
| Calcium signaling pathway | HRH1,TACR3A,PPP3R1B,STIM1,PLCB3,ADRA1BB,EDNRBA,ADCY1B,ADRB3A,ATP2B1 |
Protein Function
CHRM3 has several biochemical functions, for example, G-protein coupled acetylcholine receptor activity,acetylcholine binding,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CHRM3 itself. We selected most functions CHRM3 had, and list some proteins which have the same functions with CHRM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol phospholipase C activity | PLCD1,CCR1,PLCD3,PLCD1B,CCKBR,PLCG1,PLD4,PLCB3,PLCD1A,PLCL2 |
| drug binding | ADH1,SRP54,PYGB,DRD4,TYMS,PNP,GSTP2,ATP5O,CHRM2,CHRNB3 |
| receptor activity | CD2,EXTL3,PVR,ROBO4,ATP6AP2,ATRN,CRTAM,GP6,ANTXR2,PAQR9 |
| G-protein coupled acetylcholine receptor activity | CHRM5B,CHRM1,CHRM5A,CHRM2,CHRM4,CHRM2A,CHRM5 |
| protein binding | NLRC4,USP17L2,FOS,VEGFA,CGA,RBM12B,RNF220,SEPSECS,POC1A,SUPT4H1 |
| acetylcholine binding | CHRNB1,CHRNB3,CHRNB2,CHRNA7,ACHE,CHRNA4,CHRNA3,CHRFAM7A |
Interacting Protein
CHRM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHRM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHRM3.
MDM2;PPP1R9B;NALCN
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