CD74
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Official Full Name
CD74 molecule, major histocompatibility complex, class II invariant chain -
Overview
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] -
Synonyms
CD74;CD74 molecule, major histocompatibility complex, class II invariant chain;II;DHLAG;HLADG;Ia-GAMMA;HLA class II histocompatibility antigen gamma chain;p33;HLA-DR-gamma;MHC HLA-DR gamma chain;Ia-associated invariant chain;gamma chain of class II antigens;HLA-DR antigens-associated invariant chain;CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Mus musculus
- HEK293
- CHO
- Mammalian Cell
- Insect Cell
- E.coli
- Wheat Germ
- Human Cell
- HEK293T
- Mammalian cells
- Human cells
- HEK293F
- E.coli expression system
- His
- Non
- HA
- Myc&DDK
- GST
- His&T7
- His&GST
- Flag
- His&Fc&Avi
Involved Pathway
CD74 involved in several pathways and played different roles in them. We selected most pathways CD74 participated on our site, such as Antigen processing and presentation,Tuberculosis,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD74 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | IFNA14,CAMP,IFNA12,AKT2,TLR4,HLA-DPA1,FCGR2B,IFNA21,VDR,ATP6V0C |
| Antigen processing and presentation | Ctsl,HSP90AA1,HLA-DRB4,KIR2DS3,HLA-DRA,KIR2DS4,HLA-A,HSPA6,HLA-DRB1,KIR2DL1 |
| Herpes simplex infection | MAPK8,C1QBP,PTPN11B,IFNPHI3,C5,PPP1CB,PVRL2,TAF3,MHC1UEA,TAF9B |
Protein Function
CD74 has several biochemical functions, for example, MHC class II protein binding,MHC class II protein binding, via antigen binding groove,MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD74 itself. We selected most functions CD74 had, and list some proteins which have the same functions with CD74. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | NUFIP1,ERBB3,CBY1,ADIPOR1,SP100,PCBD1,NCL,GDF5,ADIPOR2,DRD2 |
| MHC class II protein binding | CD4,KRT17,MARCH8,CD74A,LAG3,CD74B |
| protein binding involved in protein folding | PFDN1,CLGN,PFDN2,PDCL3,CALR3,HSPA1A,CALR,HSPA1B,RIC3,DNAJB8 |
| MHC class II protein complex binding | HLA-DMA,HLA-DRA,HSP90AB1,ATP1B1,HSPA8,HSP90AA1,PKM,HLA-DOB,HLA-DRB1,HLA-DOA |
| protein binding | DAPK3,TLE4,PHB,CCDC55,NUDT14,OIP5,TDO2,FOXP1,ACTR10,SENP6 |
| cytokine receptor activity | CRFB15,IL12RB2,IL12RB1,PRLRA,Ifnlr1,IL28RA,CRFB6,IRX1,F3B,IL1RL1 |
| cytokine binding | IL31RA,PARK7,CSF1RA,GBP1,NRP1,TNFRSF11A,CXCR4,KITA,IL17F,NRP2 |
| beta-amyloid binding | APBB2,APBB1,APBA3,COL25A1,HBA-A2,ACHE,MAPK8IP2,APOEA,PION,APOA1 |
| nitric-oxide synthase binding | CDH2,DNM2,SLC6A4,SNTA1,ATP2B4,CAV1,SCN5A,CAMK2D,DNM3,CALM1 |
Interacting Protein
CD74 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD74 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD74.
HLA-DQA1;CXCR4;UBA1;UBE2N;UBE2V1;Map3k1;HLA-DRA;HLA-DPA1;yopM;HADHA;ltp_ebvg;yegQ;q5nem9_fratt;q5nes9_fratt;dnaJ2;hemL
Resources
Research Area
B Cell CD AntigenEpithelial Cell Markers and Intracellular Molecules
Conventional/Classical Dendritic Cells
Inflammatory/Monocyte-derived Dendritic Cells
Langerhans and Dermal Dendritic Cells
CD Antigen (Dendritic Cell Pathogen Recognition Uptake)
Macrophage Marker CD Antigen
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
Other T Cell CD Antigen
Macrophage Markers
Dendritic Cell Co-stimulatory Molecules
Dendritic Cell Pathogen Recognition/Uptake
Related Services
Related Products
References
- Zou, HLY; Li, QH; et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3493-3498(2015).
- Setti, SE; Littlefield, AM; et al. Diet-induced obesity attenuates endotoxin-induced cognitive deficits. PHYSIOLOGY & BEHAVIOR 141:1-8(2015).
