Recombinant Human CD74, Myc-DDK-Tagged

• Cat.No.: CD74-2228H
• Product Overview: Purified recombinant protein of Homosapiens CD74 molecule, major histocompatibility complex,class II invariant chain (CD74), transcript variant 1

Specification

• Cat. No.: CD74-2228H
• Description: The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: Human HEK293 cells
• Tags: C-terminal Myc/DDK
• Molecular weight: 33.3 kDa
• Endotoxin: < 0.1 EU per 1 μg of the protein by the LAL
• Purity: > 80% as determined by SDS-PAGE andCoomassie blue staining.
• Concentration: > 50 ug/ml as determined by BCA.
• Storage: Store at -80oC. Avoid repeatedfreeze-thaw cycles. Stable for 3 months from receipt ofproducts under proper storage and handling conditions.
• Tag: Myc&DDK

Gene Information

• Gene Name: CD74 CD74 molecule, major histocompatibility complex, class II invariant chain [ Homo sapiens ]
• Official Symbol: CD74
• Synonyms: CD74 molecule, major histocompatibility complex, class II invariant chain; DHLAG; HLADG; Ia-GAMMA; CD74; HLA class II histocompatibility antigen gamma chain; ii; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; ia antigen-associated invariant chain; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 antigen
• Gene ID: 972
• mRNA Refseq: NM_004355
• Protein Refseq: NP_004346
• MIM: 142790
• UniProt ID: P04233
• Chromosome Location: 5q32
• Pathway: Antigen processing and presentation
• Function: MHC class II protein binding; beta-amyloid binding; cytokine binding; cytokine receptor activity; identical protein binding