Native Human Apolipoprotein E

• Cat.No.: APOE-5283H
• Product Overview: Native human APOE was expressed in Human Plasma.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: The humanApolipoprotein E (APOE), is 299 amino acids long and transports lipoproteins,fat-soluble vitamins, and cholesterol into the lymph system and then into theblood. APOE is synthesized principally in the liver, but has also been foundin other tissues such as the brain, kidneys, and spleen. In the nervoussystem, non-neuronal cell types, most notably astroglia and microglia, arethe primary producers of APOE, while neurons preferentially express thereceptors for APOE. Concentration in normal plasma is 5 mg/dl. APOE isinvolved with triglyceride, phospholipid, cholesteryl ester, and cholesteroltransport in and out of cells and is a ligand for LDL receptors.
• Form: Liquid in 75mM PBSpH 7.4 + 75 mM NaCL + 0.5 M EDTA.
• Molecular Weight: 34-37 kDa
• Purity: > 98% by SDS-PAGE
• Concentration: Typically 1 mg/mL
• Storage: Store at -20 oC. Avoidrepeated freeze-thaw cycles.
• Pathways: Alzheimer"s disease; Chylomicron-mediatedlipid transport; HDL-mediated lipid transport; Lipid digestion; Lipoproteinmetabolism; Metabolism of lipids and lipoproteins; Statin Pathway

Gene Information

• Gene Name: APOE apolipoprotein E [ Homosapiens ]
• Official Symbol: APOE
• Synonyms: APOE; apolipoproteinE; AD2;LPG; LDLCQ5; MGC1571; apolipoprotein E; apo-E; apolipoprotein E3;OTTHUMP00000159143; OTTHUMP00000197075; OTTHUMP00000197076;OTTHUMP00000197077
• Gene ID: 348
• mRNA Refseq: NM_000041
• Protein Refseq: NP_000032
• MIM: 107741
• UniProt ID: P02649
• Chromosome Location: 19q13.31
• Function: antioxidantactivity; beta-amyloid binding; cholesterol transporter activity; heparinbinding; identical protein binding; lipid binding; lipid transporteractivity; lipoprotein particle binding; low-density lipoprotein particlereceptor binding; metal chelating activity; phosphatidylcholine-sterolO-acyltransferase activator activity; phospholipid binding; protein binding;protein heterodimerization activity; tau protein binding; very-low-densitylipoprotein particle receptor binding