Native Human Apolipoprotein E

• Cat.No.: APOE-5336H
• Product Overview: Native human APOEwas expressed in Human Plasma.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: Chylomicron remnantsand Very Low Density Lipoprotein (VLDL) remnants are rapidly removed from thecirculation by receptor-mediated endocytosis in the liver. Apolipoprotein E(APOE), a main apoprotein of the chylomicron, binds to a specific receptor onliver cells and peripheral cells. APOE serves as a ligand for low densityreceptors and participates in the transport and redistribution of cholesteroland other lipids. Other functions include immunoregulation and cell growthmodulation and differentiation. APOE is thought to be involved in tissuerepair as increased amounts of the protein are found at sites of peripheralnerve injury and regeneration. APOE is essential for the normal catabolism oftriglyceride-rich lipoprotein constituents.
• Form: Frozen Liquid in 50mM NH4HCO3, pH 8.0.
• Molecular Weight: 34 kDa
• Purity: > 95% by SDS-PAGE
• Certification: Prepared from fresh,non-frozen plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, andnegative for anti-HIV 1 & 2 by FDA approved tests.
• Storage: Store at -80oC.
• Pathways: Alzheimer"s disease; Chylomicron-mediatedlipid transport; HDL-mediated lipid transport; Lipid digestion; Lipoproteinmetabolism; Metabolism of lipids and lipoproteins; Statin Pathway

Gene Information

• Gene Name: APOE apolipoprotein E [ Homosapiens ]
• Official Symbol: APOE
• Synonyms: APOE; apolipoproteinE; AD2;LPG; LDLCQ5; MGC1571; apolipoprotein E; apo-E; apolipoprotein E3;OTTHUMP00000159143; OTTHUMP00000197075; OTTHUMP00000197076;OTTHUMP00000197077
• Gene ID: 348
• mRNA Refseq: NM_000041
• Protein Refseq: NP_000032
• MIM: 107741
• UniProt ID: P02649
• Chromosome Location: 19q13.31
• Function: antioxidantactivity; beta-amyloid binding; cholesterol transporter activity; heparin binding;identical protein binding; lipid binding; lipid transporter activity;lipoprotein particle binding; low-density lipoprotein particle receptorbinding; metal chelating activity; phosphatidylcholine-sterolO-acyltransferase activator activity; phospholipid binding; protein binding;protein heterodimerization activity; tau protein binding; very-low-densitylipoprotein particle receptor binding