SAA1
-
Official Full Name
serum amyloid A1 -
Overview
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11. -
Synonyms
SAA1;serum amyloid A1;SAA;serum amyloid A protein;PIG4;TP53I4;tumor protein p53 inducible protein 4;SAA2;MGC111216
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Cat
- Dog
- Monkey
- Feline
- Sheep
- Horse
- Rabbit
- Bovine
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Yeast
- Mammalian cells
- E. coli
- GST
- His
- Non
- His&B2M
- His&GST
- Myc&DDK
- His&Fc&Avi
- His&Myc&SUMO
- Flag
- His&SUMO
Involved Pathway
SAA1 involved in several pathways and played different roles in them. We selected most pathways SAA1 participated on our site, such as Activated TLR4 signalling,Advanced glycosylation endproduct receptor signaling,Amyloid formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amyloid formation | TGFBI,CALCA,NAT8,HIST3H2BB,MFGE8,ODAM,TTR,NAT8B,CEACAM21,LTF |
| Class A/1 (Rhodopsin-like receptors) | PYYA,ADRB3,NPB,CCRL2,GPR77,INSL5,NPSR1,CHRM4,POMCB,PTGDR2 |
| Cytosolic sensors of pathogen-associated DNA | TREX1,APPA,TICAM1,IFI16,NLRP4B,POLR3H,POLR3F,DDX41,DHX9,NLRP4 |
| Folate Metabolism | SAA2-SAA4,SAA4,ABCA1,AHCY,SAA2 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | DHX9,APPB,ALCAMB,S100B,CHST13,APPA,AGER,S100A12 |
| Binding and Uptake of Ligands by Scavenger Receptors | APOA1B,APOBB.1,COL1A1,HPX,IGLC2,AMBP,STAB2,SPARC,HYOU1,HSPH1 |
| Advanced glycosylation endproduct receptor signaling | DDOST,APPB,S100A12,S100B,LGALS3,APPA,AGER,ALCAMB |
| Activated TLR4 signalling | AGER,MAPK14,SIGIRR,UBE2V1,IRAK3,PELI2,CREB1,APPA,MAPKAPK2B,DUSP3B |
Protein Function
SAA1 has several biochemical functions, for example, G-protein coupled receptor binding,chemoattractant activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAA1 itself. We selected most functions SAA1 had, and list some proteins which have the same functions with SAA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heparin binding | LRPAP1,LTF,CTGFB,SOST,CCL23,TGFBR3,APLP1,ANG,COL13A1,FGFR2 |
| G-protein coupled receptor binding | GNA13A,ITGB4,SFTPBB,GNA11B,GNAV1,ARHGEF12,APLN,UCN2,INSL3,SFTPB |
| chemoattractant activity | CCL3,VEGFB,SAA4,MIF,CCL15,VHL,CCL5,PDGFB,VEGFC,BMP4 |
Interacting Protein
SAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAA1.
d-mannose
Resources
Research Area
AdipocytokinesLipid and Fatty Acid Transport
Acute Phase Proteins
Complement Regulatory Proteins
Colon Cancer Biomarkers
Head and Neck Cancer Biomarkers
Related Services
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References
- Gouwy, M; De Buck, M; et al. Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines. EUROPEAN JOURNAL OF IMMUNOLOGY 45:101-112(2015).
- Matsui, S; Yamane, T; et al. Calcitonin Gene-Related Peptide Upregulates Serum Amyloid A Synthesis through Activation of Interleukin-6. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 77:2151-2153(2013).
