Recombinant Human Serum Amyloid A1, His-tagged

• Cat.No.: SAA1-5110H
• Product Overview: Recombinant SAA1protein was expressed in E. coli and purified by using conventionalchromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Serum amyloidA1(SAA1) protein is made primarily in the liver and circulates in low levelsin the blood. This protein appears to play a role in the immune system.Levels of this protein increase in the blood and other tissues underconditions of inflammation. SAA1 may help repair damaged tissues, acts as anantibacterial agent, and signal the migration of germ-fighting cells to sitesof infection. Elevated levels of SAA over time predispose secondaryamyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulatingprecursor, in various tissues and organs. The most common form of amyloidosisoccurs secondary to chronic inflammatory disease, particularly rheumatoidarthritis.
• Concentration: 1 mg/ml
• Form: Suppliedas a liquid in 20mM Tris buffer, pH 8.0, containing 10% glycerol.
• Purity: > 95% by SDS -PAGE
• Sequence: 19-122 amino acids:MGSSHHHHHH SSGLVPRGSH MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGPGGVWAAEAIS DARENIQRFF GHGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY
• Molecular Mass: 13.9 kDa(125aa), confirmed by MALDI-TOF.
• Applications: SDS-PAGE
• Storage: Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: SAA1

Gene Information

• Gene Name: SAA1serum amyloid A1 [ Homo sapiens ]
• Synonyms: SAA1; serum amyloid A1; SAA; PIG4; SAA2; TP53I4; MGC111216; serumamyloid A protein; OTTHUMP00000232000; OTTHUMP00000232001;OTTHUMP00000236629; tumor protein p53 inducible protein 4
• Gene ID: 6288
• mRNA Refseq: NM_000331
• Protein Refseq: NP_000322
• MIM: 104750
• UniProt ID: P02735
• Chromosome Location: 11p15.1
• Pathway: ActivatedTLR4 signalling; Advanced glycosylation endproduct receptor signaling;Amyloids; Class A/1 (Rhodopsin-like receptors); Folate Metabolism; Formylpeptide receptors bind formyl peptides and many other ligands; G alpha (i)signalling events; GPCR ligand binding; Immune System; Innate ImmunitySignaling; MyD88 dependent cascade initiated on endosome; RIG-I/MDA5 mediatedinduction of IFN-alpha/beta pathways; Selenium Pathway; Toll Like Receptor 10(TLR10) Cascade; Toll Receptor Cascades; Viral dsRNA:TLR3:TRIF ComplexActivates RIP1
• Function: G-protein-coupledreceptor binding