IGF1R
-
Official Full Name
insulin-like growth factor 1 receptor -
Overview
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] -
Synonyms
IGF1R;insulin-like growth factor 1 receptor;IGFR;CD221;IGFIR;JTK13;IGF-I receptor;soluble IGF1R variant 1;soluble IGF1R variant 2;insulin-like growth factor I receptor
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Rhesus macaque
- Chicken
- Mouse
- Canine
- Porcine
- Xenopus laevis
- E.coli
- Human Cells
- HEK293
- Insect Cells
- C-His
- Mammalian Cells
- S.frugiperda
- Sf9 Cells
- Human
- Mouse
- CHO
- Yeast
- His
- GST&His
- Flag
- Non
- His&T7
- Flag&His
- GST
- Fc
- Avi&His
- Avi&Fc&His
- DDK&Myc
- His&Strep
Involved Pathway
IGF1R involved in several pathways and played different roles in them. We selected most pathways IGF1R participated on our site, such as Ras signaling pathway,Rap signaling pathway,HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Melanoma | PIK3R3,FGF5,PDGFD,FGF19,FGF10,FGF18,CDH1,PTEN,Pdgfa&Pdgfb,FGF12 |
| Ras signaling pathway | RHOA,FGFR2,RASAL2,NGFR,RAB5B,Pdgfa&Pdgfb,TBK1,FGF9,FGF4,NRAS |
| HIF- signaling pathway | VEGFA,MAP2K1,PLCG1,NOS2,ANGPT4,LDHA,HK2,FLT1,MAP2K2,PFKFB3 |
| Oocyte meiosis | PPP3R2,ANAPC13,PPP3CC,ADCY1A,CPEB4,YWHAB,BTRC,CALM2A,CALM1A,BUB1 |
| Proteoglycans in cancer | RAC1,PPP1R12C,PIK3CA,DDX5,RRAS,ACTG1,ITGAV,ERBB2,CAV1,WNT2B |
| Glioma | HRAS,PRKCA,CALM4,RAF1,PRKCG,CAMK2D,PIK3R5,RB1,PRKCB,PDGFB |
| Long-term depression | GRID2,MAPK3,GNAI3,ITPR1,RAF1,RYR1,PRKCG,PPP2R1B,GRM1,ITPR3 |
| PIK-Akt signaling pathway | GNG4,FGF12,GNB4,LPAR5,KIT,IFNA12,VEGFA,PDGFRA,RPS6KB2,TLR2 |
| Endocytosis | ARFGAP3,RAB10,AGAP2,ARF6B,PRKCI,ADRBK2,TGFB2,HGS,MHC1UXA2,CXCR1 |
Protein Function
IGF1R has several biochemical functions, for example, ATP binding,G-protein alpha-subunit binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF1R itself. We selected most functions IGF1R had, and list some proteins which have the same functions with IGF1R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | VARS2,SMC3,ACSF2,FGFR2,DDX41,PSMC6,ERCC6,PAPOLG,DNA2,PRPS1L1 |
| insulin receptor substrate binding | INSRB,PTPN11,PIK3CA,GRB2,PIK3CB,INSRA,IGF1RA,INSR,INSRR,JAK2 |
| protein binding | USE1,CDH2,MAPK4,GRM6,ELAVL2,VASN,KHK,CAB39,OOEP,NOP56 |
| insulin-like growth factor binding | IGFBP1B,IGF1RA,HTRA1A,WISP1A,IGFALS,CYR61L1,IGFBP6A,WISP2,HTRA4,Igfbpl1 |
| identical protein binding | LDHB,DACT3,TRIM21,COL18A1,TRIM39,STK4,ACTN2,DAPK1,MBIP,FAS |
| insulin-like growth factor I binding | INSR,IGFBP1B,IGFBP6A,IGFBP6,IGFBP6B,IGFBP2,IGFBP5,IGFBP5A,IGFBP5B,IGFBP4 |
| insulin receptor binding | SNX4,DOK6,PTPN1,IGF2,INSL3,IRS4,INS1,FRS2A,PIK3R1,INS2 |
| insulin-like growth factor-activated receptor activity | IGF2R |
| insulin binding | HSPD1,PIK3R1,IDE,INSR,C2CD2L |
Interacting Protein
IGF1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF1R here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF1R.
YWHAB;PIK3R1;PTPN1;ARHGEF12
Resources
Research Area
Cancer Drug TargetsAdipocytokines
Endocrine Regulation of Lipid Metabolism
Peptide Receptors on VSMC
Receptor Tyrosine Kinases (RTKs)
ALS Related Molecules
Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
CD Antigen (Dendritic Cell Adhesion)
IGF Receptor
Related Services
Related Products
References
- Huang, CT; Chang, MC; et al. Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation. CANCER LETTERS 359:117-126(2015).
- Wang, YX; Zhu, LY; et al. Activation of protein synthesis in mouse uterine epithelial cells by estradiol-17 beta is mediated by a PKC-ERK1/2-mTOR signaling pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:E1382-E1391(2015).
