Recombinant Human Insulin-like Growth Factor 1 Receptor, GST-His

• Cat.No.: IGF1R-2654H
• Product Overview: Recombinant human IGF-1R was fused at the N-terminus to a GST-His6-thrombin cleavage site sequence and expressed inS. frugiperdainsect cells using a baculovirus expression system. MW = 76532 Da.

Specification

• Species: Human
• Source: S.frugiperda
• Tag: GST&His
• Description: IGF-1R belong to the tyrosine kinase receptor family that mediates cell survival and growth in response to its ligands, IGF-1 and IGF-2. It is also involved in the proliferation of transformed cells.
• Form: Liquid. In 100 mM NaCl, 50 mM Tris-HCL, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
• Specific Activity: ≥45 U/mg protein.
• Unit Definition: One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to Poly(Glu,Tyr)4:1 per min at 30°C using variable concentrations of ATP (0.1-2.52 µM).
• Storage: ≤ -70℃. Avoid freeze/thaw.

Gene Information

• Gene Name: IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]
• Synonyms: IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172; soluble IGF1R variant 1; soluble IGF1R variant 2; EC 2.7.10.1; CD221; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
• Gene ID: 3480
• mRNA Refseq: NM_000875
• Protein Refseq: NP_000866
• MIM: 147370
• UniProt ID: P08069
• Chromosome Location: 15q26.3
• Pathway: Adherens junction; Colorectal cancer; Endocytosis; Focal adhesion; Glioma; Long-term depression; Melanoma; Pathways in cancer; Prostate cancer
• Function: ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; nucleotide binding; phosphoinositide 3-kinase binding; receptor activity; transferase activity