Recombinant Human IGF1R

• Cat.No.: IGF1R-29114TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1213-1367 of Human IGF1 Receptor,

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 1213-1367 a.a.
• Description: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
• Tissue specificity: Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 3 fibronectin type-III domains.Contains 1 protein kinase domain.

Gene Information

• Gene Name: IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]
• Official Symbol: IGF1R
• Synonyms: IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216
• Gene ID: 3480
• mRNA Refseq: NM_000875
• Protein Refseq: NP_000866
• MIM: 147370
• Uniprot ID: P08069
• Chromosome Location: 15q26.3
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Apoptosis, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem
• Function: ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding