GAPDH
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Official Full Name
glyceraldehyde-3-phosphate dehydrogenase -
Overview
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. -
Synonyms
GAPDH;G3PD;GAPD;MGC88685;glyceraldehyde-3-phosphate dehydrogenase;OTTHUMP00000174432;OTTHUMP00000174434;Peptidyl-cysteine S-nitrosylase GAPDH;aging-associated gene 9 protein;EC 1.2.1.12;glyceraldehyde 3-phosphate dehydrogenase;EC 2.6.99;EC 1.2.1;GAPDH (N-terminal)
Recombinant Proteins
- Human
- Mouse
- Rabbit
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Chinese hamster
- E.coli
- Rabbit
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- Human Heart
- E. coli
- Non
- His
- GST
- His&T7
- Flag
- His&Fc&Avi
- His&SUMO
- Myc&DDK
- N-MBP&C-His-Avi
Involved Pathway
GAPDH involved in several pathways and played different roles in them. We selected most pathways GAPDH participated on our site, such as Glycolysis / Gluconeogenesis,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAPDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycolysis / Gluconeogenesis | LDHAL6B,PGM2,LDHC,ALDOA,GPI1,PCK1,FBP1A,PGM1,GALM,ALDH9A1A.1 |
| Alzheimers disease | LPL,NDUFA13,MT-ATP6,ATP2A1,CALML5,COX6B2,NDUFA6,PSENEN,UQCRB,CALM4 |
| Biosynthesis of amino acids | ASS1,ACO2,ARG1,PFKP,GLULA,ALDOA,PGK2,ENO1B,ACO1,ASL2 |
| HIF- signaling pathway | PIK3CA,HMOX1,TEK,IL6R,CAMK2D,ENO3,PIK3R2,INS,IFNGR2,AKT1 |
| Carbon metabolism | SUCLA2,GPT2,ENO1A,MTHFR,ACSS2L,PDHA1A,PGK1,ALDOB,PC,SDHB |
| Metabolic pathways | PTGES3B,ADKA,DHRS4,TDO2,ALDOAA,LDHBB,CDIPT,INPP5L,HYAL4,SPAM1 |
Protein Function
GAPDH has several biochemical functions, for example, NAD binding,NADP binding,glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAPDH itself. We selected most functions GAPDH had, and list some proteins which have the same functions with GAPDH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| microtubule binding | ARHGEF2,CAMSAP1B,TPPP,CETN1,MAP6,MAP1LC3C,KIF3A,MAP1B,GCAP14,JAKMIP1 |
| protein binding | TXNDC5,NDUFA4,KIF7,TEX14,MATK,YIPF4,ZNF625,DHX40,ESR1,LGALS14 |
| NAD binding | HIBADHB,LDHB,GLYR1,HSD3B4,HSD11B2,PARP1,DLD,CTBP1,AOX3,NDUFV1 |
| NADP binding | H6PD,GAPDHS,FMO2,FMO3,NDOR1,ASPDH,DPYD,CAT,NOS1,IDH1 |
| identical protein binding | PRDX3,ABCD1,CASC3,TPCN2,MAP3K13,COL18A1,DAPK2,BAIAP2,SOX10,ZDHHC17 |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | GAPDHS |
Interacting Protein
GAPDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAPDH here. Most of them are supplied by our site. Hope this information will be useful for your research of GAPDH.
EGFR;S100A8;PREP;PCNA
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References
- Bil-Lula, I; Sochocka, M; et al. Adenovirus Type 9 Enhances Differentiation and Decreases Cytokine Release from Preadipocytes. JOURNAL OF MEDICAL VIROLOGY 87:230-239(2015).
- Upadhyaya, B; Tian, XL; et al. Expression and distribution of thiol-regulating enzyme glutaredoxin 2 (GRX2) in porcine ocular tissues. EXPERIMENTAL EYE RESEARCH 130:58-65(2015).
