Recombinant Rat Col1a1 Protein, His-tagged

• Cat.No.: Col1a1-817R
• Product Overview: Recombinant Rat Col1a1 Protein (Gly22-Ser154) with His tag was expressed in E. coli.

Specification

• Description: Predicted to enable identical protein binding activity; platelet-derived growth factor binding activity; and protease binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mechanical stimulus; and cellular response to retinoic acid. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and secretory granule. Used to study cholestasis and non-alcoholic fatty liver disease. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; liver disease (multiple); pulmonary fibrosis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Ehlers-Danlos syndrome arthrochalasia type 1; aggressive periodontitis; bone disease (multiple); cutaneous leishmaniasis; and dentinogenesis imperfecta. Orthologous to human COL1A1 (collagen type I alpha 1 chain).
• Source: E. coli
• Species: Rat
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 17.4 kDa; Accurate Molecular Mass: 22 kDa
• Protein length: Gly22-Ser154
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Col1a1 collagen, type I, alpha 1 [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Col1a1
• Synonyms: COL1A1; collagen, type I, alpha 1; collagen alpha-1(I) chain; alpha-1 type I collagen; collagen, type 1, alpha 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; COLIA1
• Gene ID: 29393
• mRNA Refseq: NM_053304
• Protein Refseq: NP_445756
• UniProt ID: P02454

Reviews

10/18/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

08/13/2022

Very good after-sales service, an excellent shopping experience!

03/15/2022

The product brochure is very detailed and has comprehensive basic information about the COL1A1 protein.

Q&As

What diseases is COL1A1 involved in?

COL1A1 has been associated with the study of colorectal, gastric and pancreatic cancers.

What are the effects of inhibiting COL1A1 expression?

Inhibition of COL1A1 expression can affect the expression of various genes, thereby inhibiting tumor cell proliferation and promoting cell apoptosis.

Where is COL1A1 mainly expressed?

COL1A1 is highly expressed in heart and muscle tissues.

What are the components of COL1A1?

COL1A1 consists of three conserved structural domains, Collagen, COLFI and VWC.

What are the biological functions of COL1A1?

COL1A1 is involved in maintaining tissue structure and angiogenesis.

How does COL1A1 expression change in colorectal cancer tissues?

COL1A1 expression is significantly upregulated in colorectal cancer tissues.