Native Human collagen, type I

• Cat.No.: COL1A1-26195TH
• Product Overview: Full length native protein (purified) (Human)

Specification

• Description: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
• Source: Native
• Tissue specificity: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
• Form: Liquid
• Storage buffer: Preservative: 0.01% Sodium AzideConstituents: 0.5M Acetic acid, pH 4.5
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the fibrillar collagen family.Contains 1 fibrillar collagen NC1 domain.Contains 1 VWFC domain.
• Tag: Non

Gene Information

• Gene Name: COL1A1 collagen, type I, alpha 1 [ Homo sapiens ]
• Official Symbol: COL1A1
• Synonyms: COL1A1; collagen, type I, alpha 1; collagen alpha-1(I) chain; OI4
• Gene ID: 1277
• mRNA Refseq: NM_000088
• Protein Refseq: NP_000079
• Uniprot ID: P02452
• Chromosome Location: 17q21.33
• Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Developmental Biology, organism-specific biosystem
• Function: extracellular matrix structural constituent; identical protein binding; platelet-derived growth factor binding; protein binding

Reviews

10/18/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

08/13/2022

Very good after-sales service, an excellent shopping experience!

03/15/2022

The product brochure is very detailed and has comprehensive basic information about the COL1A1 protein.

Q&As

What diseases is COL1A1 involved in?

COL1A1 has been associated with the study of colorectal, gastric and pancreatic cancers.

What are the effects of inhibiting COL1A1 expression?

Inhibition of COL1A1 expression can affect the expression of various genes, thereby inhibiting tumor cell proliferation and promoting cell apoptosis.

Where is COL1A1 mainly expressed?

COL1A1 is highly expressed in heart and muscle tissues.

What are the components of COL1A1?

COL1A1 consists of three conserved structural domains, Collagen, COLFI and VWC.

What are the biological functions of COL1A1?

COL1A1 is involved in maintaining tissue structure and angiogenesis.

How does COL1A1 expression change in colorectal cancer tissues?

COL1A1 expression is significantly upregulated in colorectal cancer tissues.