Native Mouse collagen, type I Protein

• Cat.No.: Col1a1-7174M
• Product Overview: Collagens were extracted from washed dissected tissue into dilute acetic acid after mild pepsin treatment. Collagen type I was purified by using differential salt precipitation. Thermal denaturation converts the collagen to gelatin.

Specification

• Description: This gene encodes the alpha-1 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing.
• Source: Tissue
• Species: Mouse
• Form: Liquid
• Purity: > 90 % pure by SDS PAGE. Cross linked collagen type I dimers and trimers represent approximately 10%.
• Applications: ELISA
• Stability: Shelf life: one year from despatch.
• Storage: Store the antigen undiluted at -20 centigrade only. Avoid repeated freezing and thawing.
• Concentration: 1.0 mg/mL
• Storage Buffer: 0.5 M Acetic Acid without additives.

Gene Information

• Gene Name: Col1a1 collagen, type I, alpha 1 [ Mus musculus (house mouse) ]
• Official Symbol: Col1a1
• Synonyms: Col1a1; collagen, type I, alpha 1; Co; Col; Col1; Mov-; Cola1; Mov13; Cola-1; Mov-13; Col1a-1; collagen alpha-1(I) chain; alpha-1 type 1 collagen; alpha-1 type I collagen; procollagen, type I, alpha 1
• Gene ID: 12842
• mRNA Refseq: NM_007742
• Protein Refseq: NP_031768
• UniProt ID: P11087

Reviews

10/18/2022

Timely delivery, so I got the desired experimental results in the shortest possible time.

08/13/2022

Very good after-sales service, an excellent shopping experience!

03/15/2022

The product brochure is very detailed and has comprehensive basic information about the COL1A1 protein.

Q&As

What diseases is COL1A1 involved in?

COL1A1 has been associated with the study of colorectal, gastric and pancreatic cancers.

What are the effects of inhibiting COL1A1 expression?

Inhibition of COL1A1 expression can affect the expression of various genes, thereby inhibiting tumor cell proliferation and promoting cell apoptosis.

Where is COL1A1 mainly expressed?

COL1A1 is highly expressed in heart and muscle tissues.

What are the components of COL1A1?

COL1A1 consists of three conserved structural domains, Collagen, COLFI and VWC.

What are the biological functions of COL1A1?

COL1A1 is involved in maintaining tissue structure and angiogenesis.

How does COL1A1 expression change in colorectal cancer tissues?

COL1A1 expression is significantly upregulated in colorectal cancer tissues.