Recombinant Mouse Plasminogen Activator, Urokinase

• Cat.No.: Plau-5464M
• Product Overview: Recombinant MouseHigh Molecular Weight two-chain Urokinase Active.

Specification

• Species: Mouse
• Source: Insect Cells
• Tag: Non
• Description: Plauencodes a serine protease involved in degradation of the extracellular matrixand possibly tumor cell migration and proliferation. A specific polymorphismin this gene may be associated with late-onset Alzheimer disease and alsowith decreased affinity for fibrin-binding. Plau encoded by this geneconverts plasminogen to plasmin by specific cleavage of an Arg-Val bond inplasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasminto form a two-chain derivative in which a single disulfide bond connects theamino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.This two-chain derivative is also called Plau. Plau can be further processedinto LMW- Plau (low molecular weight Plau) by cleavage of chain A into ashort chain A (A1) and an amino-terminal fragment. LMW- Plau isproteolytically active but does not bind to the Plau receptor.
• Form: Liquid in 0.05 Msodium acetate + 0.1 M NaCl + 1 mM EDTA, pH 5.0
• Molecular Weight: 44.0 kDa
• Concentration: 2.0 mg/ml
• Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: Plau

Gene Information

• Gene Name: Plau plasminogen activator,urokinase [ Mus musculus ]
• Synonyms: Plau; plasminogenactivator, urokinase; PA; u-PA; urokinase-type plasminogen activator;U-plasminogen activator; EC 3.4.21.73
• Gene ID: 18792
• mRNA Refseq: NM_008873
• Protein Refseq: NP_032899
• UniProt ID: P06869
• Chromosome Location: 14 A3; 14 2.5 cM
• Pathway: Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Wnt Signaling Pathway; Wnt SignalingPathway and Pluripotency
• Function: catalytic activity;hydrolase activity; kinase activity; peptidase activity; serine-typeendopeptidase activity; serine-type peptidase activity