Recombinant Mouse Kl protein, His-tagged

• Cat.No.: Kl-1562M
• Product Overview: Recombinant Mouse Kl aa. (Leu59~Phe508) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: 53kDa as determined by SDS-PAGE reducing conditions.
• Protein length: Leu59~Phe508
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >92%
• Applications: SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Concentration: 200μg/mL
• Storage buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Isoelectric Point: 8.3

Gene Information

• Gene Name: Kl klotho [ Mus musculus (house mouse) ]
• Official Symbol: Kl
• Synonyms: Kl; klotho; alpha-kl; secreted form of Klotho protein
• Gene ID: 16591
• mRNA Refseq: NM_013823.2
• Protein Refseq: NP_038851.2
• UniProt ID: O35082

Reviews

01/31/2021

The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

01/22/2019

Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

07/22/2016

Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

Q&As

How does KL protein affect cognitive function?

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use?

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process?

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings?

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies?

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.