KL
-
Official Full Name
klotho -
Overview
This gene encodes a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes ( -
Synonyms
KL;klotho
Recombinant Proteins
- Mouse
- Human
- Rat
- CHO
- Mammalian cells
- HEK293
- Mammalian Cell
- E.coli
- His
- Fc
- Non
- His&SUMO
- His&GST
- His&T7
- His&Fc&Avi
Involved Pathway
KL involved in several pathways and played different roles in them. We selected most pathways KL participated on our site, such as Pentose and glucuronate interconversions,Starch and sucrose metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocrine and other factor-regulated calcium reabsorption | KLK1B5,ATP1B2,PRKCA,KLK1,KLK2,KLK1B9,TRPV5,ATP1A1,PRKACG,BDKRB2 |
| Pentose and glucuronate interconversions | UGP2B,UGP2A,UGP2,AKR1B7,GKUP,AKR1B1,UGT1A6A,UGT1A1,DHDHL,GUSB |
| Starch and sucrose metabolism | G6PCA.2,PYGB,GYS2,UGT1A2,AGLA,ENPP3,GYS1,UGT1A7,PGM2,GPI1 |
| Metabolic pathways | ACSS2,MGAT5,ATP6AP1,ASS1,GAPDH,ARG1,GCSHA,FBP1A,AGPAT6,PON3 |
Protein Function
KL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KL itself. We selected most functions KL had, and list some proteins which have the same functions with KL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCL5,PDCL,RHOJ,GLS,EME1,ECH1,GTF2IRD2,PIR,CSGALNACT2,FOXK1 |
Interacting Protein
KL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KL here. Most of them are supplied by our site. Hope this information will be useful for your research of KL.
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References
- Lee, EK; Martinez, MCR; et al. FGF23: Mediator of poor prognosis in a sizeable subgroup of patients with castration-resistant prostate cancer presenting with severe hypophosphatemia?. MEDICAL HYPOTHESES 83:482-487(2014).
- He, Y; Siebuhr, AS; et al. Type X collagen levels are elevated in serum from human osteoarthritis patients and associated with biomarkers of cartilage degradation and inflammation. BMC MUSCULOSKELETAL DISORDERS 15:-(2014).
