Recombinant Human KL

• Cat.No.: KL-29904TH
• Product Overview: Recombinant fragment, corresponding to amino acids 34-549 of Human Klotho isoform 2; 516 amino acids, 65-70 kDa.

Specification

• Description: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
• Source: CHO
• Tissue specificity: Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chro
• Biological activity: Biological Activity :Determined by the dose-dependent stimulation of the proliferation of murine NIH3T3 cells.
• Form: Lyophilised:Reconstituted KL-29904TH is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
• Purity: >95% by SDS-PAGE
• Storage: Store at -20°C. Stable for 12 months at -20°C
• Sequences of amino acids: EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH
• Sequence Similarities: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
• Tag: Non
• Protein length: 34-549

Gene Information

• Gene Name: KL klotho [ Homo sapiens ]
• Official Symbol: KL
• Synonyms: KL; klotho
• Gene ID: 9365
• mRNA Refseq: NM_004795
• Protein Refseq: NP_004786
• Uniprot ID: Q9UEF7
• Chromosome Location: 13q12
• Pathway: Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem
• Function: beta-glucosidase activity; beta-glucuronidase activity; cation binding; fibroblast growth factor binding; fibroblast growth factor receptor binding

Reviews

01/31/2021

The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

01/22/2019

Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

07/22/2016

Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

Q&As

How does KL protein affect cognitive function?

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use?

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process?

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings?

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies?

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.