Recombinant Human KL

• Cat.No.: KL-29904TH
• Product Overview: Recombinant fragment, corresponding to amino acids 34-549 of Human Klotho isoform 2; 516 amino acids, 65-70 kDa.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Protein Length: 34-549 a.a.
• Description: This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
• Tissue specificity: Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chro
• Biological activity: Biological Activity :Determined by the dose-dependent stimulation of the proliferation of murine NIH3T3 cells.
• Form: Lyophilised:Reconstituted KL-29904TH is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
• Purity: >95% by SDS-PAGE
• Storage: Store at -20°C. Stable for 12 months at -20°C
• Sequences of amino acids: EPGDGAQTWA RFSRPPAPEA AGLFQGTFPD GFLWAVGSAA YQTEGGWQQH GKGASIWDTF THHPLAPPGD SRNASLPLGA PSPLQPATGD VASDSYNNVF RDTEALRELG VTHYRFSISW ARVLPNGSAG VPNREGLRYY RRLLERLREL GVQPVVTLYH WDLPQRLQDA YGGWANRALA DHFRDYAELC FRHFGGQVKY WITIDNPYVV AWHGYATGRL APGIRGSPRL GYLVAHNLLL AHAKVWHLYN TSFRPTQGGQ VSIALSSHWI NPRRMTDHSI KECQKSLDFV LGWFAKPVFI DGDYPESMKN NLSSILPDFT ESEKKFIKGT ADFFALCFGP TLSFQLLDPH MKFRQLESPN LRQLLSWIDL EFNHPQIFIV ENGWFVSGTT KRDDAKYMYY LKKFIMETLK AIKLDGVDVI GYTAWSLMDG FEWHRGYSIR RGLFYVDFLS QDKMLLPKSS ALFYQKLIEK NGFPPLPENQ PLEGTFPCDF AWGVVDNYIQ VSQLTKPISS LTKPYH
• Sequence Similarities: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Gene Information

• Gene Name: KL klotho [ Homo sapiens ]
• Official Symbol: KL
• Synonyms: KL; klotho
• Gene ID: 9365
• mRNA Refseq: NM_004795
• Protein Refseq: NP_004786
• Uniprot ID: Q9UEF7
• Chromosome Location: 13q12
• Pathway: Ascorbate biosynthesis, animals, glucose-1P => ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Downstream signaling of activated FGFR, organism-specific biosystem
• Function: beta-glucosidase activity; beta-glucuronidase activity; cation binding; fibroblast growth factor binding; fibroblast growth factor receptor binding