Recombinant Mouse Il36rn Protein, Myc/DDK-tagged

• Cat.No.: Il36rn-3505M
• Product Overview: Purified recombinant protein of mouse full-length interleukin 1 family, member 5 (delta) (Il1f5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Myc&DDK
• Description: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
• Molecular Mass: 17.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Il36rn interleukin 36 receptor antagonist [ Mus musculus (house mouse) ]
• Official Symbol: Il36rn
• Synonyms: IL1F5; interleukin 1 family, member 5 (delta); interleukin-36 receptor antagonist protein; IL-1F5; IL-1L1; IL-1HY1; IL-1 delta; interleukin-1 HY1; interleukin-1 delta; interleukin-1 homolog 3; interleukin-1-like protein 1; interleukin-1 family member 5; interleukin 1 receptor antagonist homolog 1; IL36RN; Il-1h3; Il1hy1; AI413231; Fil1delta
• Gene ID: 54450
• mRNA Refseq: NM_001146087
• Protein Refseq: NP_001139559
• UniProt ID: Q9QYY1