Recombinant Mouse Cradd Protein, Myc/DDK-tagged

• Cat.No.: Cradd-2304M
• Product Overview: Purified recombinant protein of mouse full-length CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 22.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cradd CASP2 and RIPK1 domain containing adaptor with death domain [ Mus musculus (house mouse) ]
• Official Symbol: Cradd
• Synonyms: CRADD; CASP2 and RIPK1 domain containing adaptor with death domain; death domain-containing protein CRADD; caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CASP2 and RIPK1 domain-containing adaptor with death domain; RAIDD
• Gene ID: 12905
• mRNA Refseq: NM_009950
• Protein Refseq: NP_034080
• UniProt ID: O88843