CRADD
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Official Full Name
CASP2 and RIPK1 domain containing adaptor with death domain -
Overview
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq, Jul 2008] -
Synonyms
CRADD;CASP2 and RIPK1 domain containing adaptor with death domain;MRT34;RAIDD;death domain-containing protein CRADD;death adaptor molecule RAIDD;caspase and RIP adaptor with death domain;RIP-associated protein with a death domain;RIP-associated ICH1/CED3-homologous protein with death domain
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Chicken
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- E. coli
- His
- GST
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
CRADD involved in several pathways and played different roles in them. We selected most pathways CRADD participated on our site, such as Apoptosis,Apoptosis Modulation and Signaling,Caspase cascade in apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Caspase cascade in apoptosis | ACTA1,TOP1,DFFA,SATB1,CASP2,DIABLO,CFL2,PARP1,NUMA1,GAS2 |
| Apoptosis Modulation and Signaling | BCL2L11,CAPNS1,CASP2,BLK,SEPT4,HN1,BAG3,BOK,HRK,DAXX |
| Ceramide signaling pathway | DERL3,CTSD,PAWR,EGF |
| HIV-1 Nef: Negative effector of Fas and TNF-alpha | DFFA,CASP2,DAXX |
| Apoptosis | STK24B,BCL2,AKT1,BIRC7,RIPK1L,MYD88,DIABLO,CASP6,PRKAR2A,PIK3R3 |
| TNF-alpha/NF-kB Signaling Pathway | RNF216,TRAIP,FAF1,PAPOLA,COPS3,NKIRAS1,KIAA1967,AKAP8,KTN1,DDX3X |
Protein Function
CRADD has several biochemical functions, for example, death domain binding,protease binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRADD itself. We selected most functions CRADD had, and list some proteins which have the same functions with CRADD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protease binding | MBL1,OS9,TYSND1,NFRKB,TIMP4,SERPINC1,LDLR,ITGB1,FAP,LRP1 |
| death domain binding | DAPL1,TRADD,DAP1B,DAP,RIPK1 |
| protein binding | KAT7,NAT8B,P4HB,MCCC1,PMS2,BSX,MAGEA11,PKP4,ZSCAN21,EDDM3B |
| protein binding, bridging | FSCN2A,PPP4R2,MMS19,IVL,DSP,FGB,SYNM,AMFR,COL8A2,SPRR1A |
Interacting Protein
CRADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRADD here. Most of them are supplied by our site. Hope this information will be useful for your research of CRADD.
CASP2;PIDD1
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