Recombinant Human TTR (L55P) Protein (Full Length)

Description :	This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.
Source :	E. coli
Species :	Human
Protein length :	Full Length
Purity :	> 95% pure using SDS-PAGE analysis.
Applications :	WB, SDS-PAGE, In vivo assay, In vitro assay
Notes :	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Storage :	At -80 centigrade.
Storage Buffer :	PBS pH 7.4
Shipping :	Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

Gene Name	TTR transthyretin [ Homo sapiens (human) ]
Official Symbol	TTR
Synonyms	TTR; transthyretin; CTS; TTN; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651; transthyretin; epididymis luminal protein 111; prealbumin, amyloidosis type I; thyroxine-binding prealbumin
Gene ID	7276
mRNA Refseq	NM_000371
Protein Refseq	NP_000362
MIM	176300
UniProt ID	P02766