Recombinant Human TLE1 Protein, MYC/DDK-tagged

• Cat.No.: TLE1-22H
• Product Overview: Recombinant protein of human transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) (TLE1) with C-MYC/DDK tag was expressed in HEK293T.

Specification

• Description: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
• Source: HEK293T
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 83 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at –80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: TLE1
• Official Symbol: TLE1 transducin like enhancer of split 1 [ Homo sapiens (human) ]
• Synonyms: TLE1; transducin like enhancer of split 1; ESG; ESG1; GRG1; transducin-like enhancer protein 1; enhancer of split groucho-like protein 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
• Gene ID: 7088
• mRNA Refseq: NM_005077
• Protein Refseq: NP_005068
• MIM: 600189
• UniProt ID: Q04724