TLE1

  • Official Full Name

    transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

  • Overview

    Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.

  • Synonyms

    TLE1;transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila);transducin like enhancer of split 1, homolog of Drosophila E(sp1);transducin-like enhancer protein 1;enhancer of split groucho 1;ESG;ESG1;GRG1;E(Sp1) homolog;Enhancer of split groucho like protein 1;Enhancer of split groucho-like protein 1;TLE 1;TLE1_HUMAN;Transducin like enhancer of split 1 (E(sp1) homolog Drosophila);Transducin like enhancer of split 1;Transducin like enhancer of split 1 homolog of Drosophila E(sp1);Transducin like enhancer protein 1;transducin-like enhancer of split 1, homolog of Drosophila E(sp1)

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Mammalian cells
  • His
  • Non
  • His&Fc&Avi
  • Myc&DDK
  • Flag

    Involved Pathway

    TLE1 involved in several pathways and played different roles in them. We selected most pathways TLE1 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Degradation of beta-catenin by the destruction complex,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deactivation of the beta-catenin transactivating complex SOX4A,SOX32,BCL9,SOX4B,TLE3B,RBBP5,SOX9A,TLE4,CBY1,SOX13
    Degradation of beta-catenin by the destruction complex TLE2,TLE4,FAM123B,AES,TLE3B,CTBP2,CTBP1,TLE3
    Notch-mediated HES/HEY network RCAN1,GATA1,BGLAP,YY1,CTBP1,MYB,MYOD1,HES6,GATA6,ASCL1
    Formation of the beta-catenin:TCF transactivating complex RBBP5,BCL9,CDC73,BCL9L,LEO1,TLE2,PYGO2,ASH2L,H3F3B.1,SMARCA4
    Presenilin action in Notch and Wnt signaling KREMEN2,AES,WIF1
    Delta-Notch Signaling Pathway TCF3B,CNTFR,HEY2,JAG1,ADAM10A,ZFPM1,CNTF,JAG2,CNTN1B,SAP30
    NOTCH1 Intracellular Domain Regulates Transcription HEY2,HEYL,TLE2,TLE4,TUBB3,HEY1,TLE3
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription HBP1,TNIK,TLE4,AES,CBY1,BCL9,CDX4,IGF2BP1,KRT1,CYR61

    Protein Function

    TLE1 has several biochemical functions, for example, RNA polymerase II transcription corepressor activity,chromatin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE1 itself. We selected most functions TLE1 had, and list some proteins which have the same functions with TLE1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding AP5S1,SULT1E1,WWP2,IMMT,NUFIP2,SYT11,IQUB,GPR50,AGO3,SRSF10
    identical protein binding BCL2L1,CORO1B,CLDN15,TYROBP,PTPRM,PSMD4,SELK,FRS3,CLDN3,CSNK2B
    chromatin binding EYA3,POLG,RNF20,SMAD4,ZGLP1,COQ7,CDC45,DNMT1,NAP1L2,PATZ1
    transcription factor binding MYBBP1A,NFATC3,BRD7,NBN,GTF2A1,THRA,KDM1A,NEUROD1,BPTF,MYC
    RNA polymerase II transcription corepressor activity TBX18,CITED2,SIN3B,TBX15,HDAC1,SIN3A,NFIB,UXT,BEND6,OLIG3

    Interacting Protein

    TLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE1.

    RUNX1;RUNX3;TK1;DAZAP2;HIPK2;SYT-SSX2

    Resources

    References

    • Endo, M; Su, L; et al. Activating transcription factor 2 in mesenchymal tumors. HUMAN PATHOLOGY 45:276-284(2014).
    • Valente, AL; Tull, J; et al. Specificity of TLE1 Expression in Unclassified High-grade Sarcomas for the Diagnosis of Synovial Sarcoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 21:408-413(2013).

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