TLE1

  • Official Full Name

    transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

  • Overview

    Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.

  • Synonyms

    TLE1;transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila);transducin like enhancer of split 1, homolog of Drosophila E(sp1);transducin-like enhancer protein 1;enhancer of split groucho 1;ESG;ESG1;GRG1;E(Sp1) homolog;Enhancer of split groucho like protein 1;Enhancer of split groucho-like protein 1;TLE 1;TLE1_HUMAN;Transducin like enhancer of split 1 (E(sp1) homolog Drosophila);Transducin like enhancer of split 1;Transducin like enhancer of split 1 homolog of Drosophila E(sp1);Transducin like enhancer protein 1;transducin-like enhancer of split 1, homolog of Drosophila E(sp1)

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mammalian Cells
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag

    Involved Pathway

    TLE1 involved in several pathways and played different roles in them. We selected most pathways TLE1 participated on our site, such as Deactivation of the beta-catenin transactivating complex,Degradation of beta-catenin by the destruction complex,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Formation of the beta-catenin:TCF transactivating complex TLE2,BCL9,RBBP5,TLE3,ASH2L,TLE4,PYGO1,TLE3B,SMARCA4,CDC73
    Deactivation of the beta-catenin transactivating complex ASH2L,TLE4,TLE2,SOX9A,CTBP1,SOX4B,RBBP5,SOX7,PYGO2,TLE3
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription IGF2BP1,TCF4,CYR61,T,SALL4,KCNIP4,HBP1,CDX4,TLE2,CBY1
    Degradation of beta-catenin by the destruction complex CTBP2,TLE2,TLE3,TLE4,FAM123B,AES,CTBP1,TLE3B
    Delta-Notch Signaling Pathway ADAM10A,CNTF,ASCL1A,NOV,APPA,SAP30,HEY2,SMAD3B,HES6,YY1A
    Presenilin action in Notch and Wnt signaling AES,KREMEN2,WIF1
    Notch-mediated HES/HEY network GATA6,HEY1,YY1,MYOD1,HES6,BGLAP,MYB,ASCL1,CTBP1,GATA1
    NOTCH1 Intracellular Domain Regulates Transcription HEY2,HEY1,TLE3,HEYL,TUBB3,TLE2,TLE4

    Protein Function

    TLE1 has several biochemical functions, for example, RNA polymerase II transcription corepressor activity,chromatin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE1 itself. We selected most functions TLE1 had, and list some proteins which have the same functions with TLE1. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor binding DIP2BA,TRAPPC2,RNF222,NFATC3,KCNA3,KCTD1,FOXA3,STK4,STAT3,DIP2B
    protein binding PDCD6,HPGDS,NDRG4,ITGB7,TNFSF12,MED21,SLC22A3,ANKRD1,CX3CL1,PIK3C3
    chromatin binding NKAP,CENPB,MLL1,NCAPD3,SIX1,SKIL,TAF2,HMGB2B,SOX14,HMGXB4A
    RNA polymerase II transcription corepressor activity NFIB,CTBP1,RBBP8,N4BP2L2,OLIG3,BEND6,URI1,TXLNB,TFAP2B,UXT
    identical protein binding CEP72,GRB7,KCNJ2,CASP6,ALCAMB,APOE,PITX2,CHAF1A,CEACAM16,S100A2

    Interacting Protein

    TLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE1.

    RUNX1;RUNX3;TK1;DAZAP2;HIPK2;SYT-SSX2

    Resources

    References

    • Endo, M; Su, L; et al. Activating transcription factor 2 in mesenchymal tumors. HUMAN PATHOLOGY 45:276-284(2014).
    • Valente, AL; Tull, J; et al. Specificity of TLE1 Expression in Unclassified High-grade Sarcomas for the Diagnosis of Synovial Sarcoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 21:408-413(2013).

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