Recombinant Human Thyroid Peroxidase

• Cat.No.: TPO-701H
• Product Overview: Recombinant human TPOis expressed from human 293 cells as a monomeric glycoprotein with anapparent molecular mass of 80 to 85 kDa.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: This cytokine isproduced in a serum-free, chemically defined media. Production in human 293cells offers authentic glycosylation, contributing to stability in cellgrowth media and other applications. C terminal domain glycosylation is thoughtto be important for the secretion of TPO from cells and for survival of TPOin the circulation. The purity is greater than 90%.
• MolecularWeight: 80 to 85 kDa,monomer, glycosylated
• Purity: >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
• Endotoxin Level: Endotoxin Free<1 EU/µg
• Biological Activity: 0.5 to 5 ng/mL ED50
• Specific Activity: The specificactivity was determined by the dose-dependent stimulation of the proliferationof human TF-1 cells (human erythroleukemic indicator cell line).
• OfficialSymbol: TPO

Gene Information

• Gene Name: TPO thyroid peroxidase [ Homosapiens ]
• Synonyms: TPO; thyroidperoxidase; MSA; TPX; TDH2A; thyroperoxidase; OTTHUMP00000115303;OTTHUMP00000115304; OTTHUMP00000115535; OTTHUMP00000115536; thyroidmicrosomal antigen; EC 1.11.1.8; EC 1.11.1
• Gene ID: 7173
• mRNA Refseq: NM_000547
• Protein Refseq: NP_000538
• MIM: 606765
• UniProt ID: P07202
• Chromosome Location: 2p25
• Pathway: Amine-derivedhormones; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction;Hematopoietic cell lineage; Jak-STAT signaling pathway; Metabolic pathways;Metabolism; Metabolism of amino acids and derivatives; Thyroid hormonebiosynthesis; Thyroxine biosynthesis; Tyrosine metabolism
• Function: calcium ion binding;heme binding; iodide peroxidase activity; oxidoreductase activity; peroxidaseactivity