TPO
-
Official Full Name
thyroid peroxidase -
Overview
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. -
Synonyms
TPO;thyroid peroxidase;MSA;TPX;TDH2A;thyroperoxidase;thyroid microsomal antigen;EC 1.11.1.8;Thyroid peroxidase
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- HEK293
- E.coli
- Human Thyroids
- CHO
- Insect Cells
- Insect cells
- Mammalian Cells
- Human Cells
- Yeast
- Fc
- Non
- His
- DDK
- Myc
- Flag
- Avi
Involved Pathway
TPO involved in several pathways and played different roles in them. We selected most pathways TPO participated on our site, such as Tyrosine metabolism,Metabolic pathways,Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Thyroid hormone synthesis | PLCB3,SLC5A5,CREB3L3,FXYD2,PLCB2,CREB3L1,IYD,ATP1A4,TSHB,GPX7 |
| Metabolic pathways | ATP5G3,GALNT14,SUCLG2,ACSL1A,PYGL,GCSHA,ALDH5A1,CMBL,PISD,AMD1 |
| Autoi | HLA-DPB1,HLA-DRB4,PRF1,IFNA14,FASLG,HLA-DQB1,TSHB,Il2,Fasl,TG |
| Tyrosine metabolism | TYR,ADH2-1,TYRP1,MAOA,DBH,ALDH3B2,COMTA,AOC3,AOX3,HPDB |
| ne thyroid disease | CD28,HLA-DQB1,IFNA14,IFNA13,H2-AB1,IL5,TG,Il2,CD40LG,IFNA2 |
Protein Function
TPO has several biochemical functions, for example, calcium ion binding,heme binding,iodide peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPO itself. We selected most functions TPO had, and list some proteins which have the same functions with TPO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CDH8,CAPN12,PCDH1GB9,TNNC1B,RHOT1A,DMP1,NINL,PROC,MMP24,SNCB |
| heme binding | CYP2C54,CYP2AD6,CYGB1,CYP2C8,CYP46A1.4,CYP1A1,CYP2Y3,CBSA,AMBP,PXDN |
| iodide peroxidase activity | IYD |
| peroxidase activity | GPX4A,PTGS2A,MGST3,PRDX5,GPX5,GPX8,MPO,IPCEF1,MPX,GPX6 |
Interacting Protein
TPO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPO here. Most of them are supplied by our site. Hope this information will be useful for your research of TPO.
Resources
Research Area
Myeloid Lineage MarkersOsteoclast Markers
Osteoblast and Osteoclast Markers
Osteogenesis Markers
Megakaryocytes
Osteoprogenitor Markers
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References
- Brown, AS; Surcel, HM; et al. Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 57:86-92(2015).
- Chan, S; Boelaert, K; et al. Optimal management of hypothyroidism, hypothyroxinaemia and euthyroid TPO antibody positivity preconception and in pregnancy. CLINICAL ENDOCRINOLOGY 82:313-326(2015).
