Recombinant Human TARDBP, MYC/DDK-tagged

• Cat.No.: TARDBP-35H
• Product Overview: Recombinant Human TARDBP, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
• Molecular Mass: 44.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: TARDBP TAR DNA binding protein [ Homo sapiens (human) ]
• Official Symbol: TARDBP
• Synonyms: TARDBP; TDP-43; TAR DNA binding protein; ASL 10; TAR DNA-binding protein 43; TDP43; TAR DNA-binding protein 43; OTTHUMP00000002173; TRA DNA-binding protein-43
• Gene ID: 23435
• mRNA Refseq: NM_007375
• Protein Refseq: NP_031401
• MIM: 605078
• UniProt ID: Q13148
• Chromosome Location: 1p36.22
• Function: RNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; double-stranded DNA binding