Recombinant Human ST3GAL3 Protein (AA 60-375), N-6×His/GFP tagged

• Cat.No.: ST3GAL3-12H
• Product Overview: Recombinant Human ST3GAL3 Protein (AA 60-375) with N-6×His/GFP tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: His&GFP
• Molecular Mass: ~60-70 kDa
• Protein length: AA 60-375
• AA Sequence: ELATKYANFSEGACKPGYASALMTA IFPRFSKPAPMFLDDSFRKWARIRE FVPPFGIKGQDNLIKAILSVTKEYR LTPALDSLRCRRCIIVGNGGVLANK SLGSRIDDYDIVVRLNSAPVKGFEK DVGSKTTLRITYPEGAMQRPEQYER DSLFVLAGFKWQDFKWLKYIVYKER VSASDGFWKSVATRVPKEPPEIRIL NPYFIQEAAFTLIGLPFNNGLMGRG NIPTLGSVAVTMALHGCDEVAVAGF GYDMSTPNAPLHYYETVRMAAIKES WTHNIQREKEFLRKLVKARVITDLS SGI
• Purity: >95%, by SDS-PAGE as visualized by Coomassie Blue Staining
• Stability: 6 months if stored at -80 centigrade. Avoid repeated freeze thaws.
• Concentration: 1 mg/mL
• Storage Buffer: Supplied as a 0.2 μm filtered solution in 20mM HEPES pH 7.0 and 100mM NaCl buffer, with 10% Glycerol.
• Preservative: 0.05 % NaN3
• Shipping: This product is shipped as 0.2μm filtered product on dry ice.

Gene Information

• Gene Name: ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Homo sapiens (human) ]
• Official Symbol: ST3GAL3
• Synonyms: ST3GAL3; ST3 beta-galactoside alpha-2,3-sialyltransferase 3; sialyltransferase 6 (N acetyllacosaminide alpha 2,3 sialyltransferase) , SIAT6; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; ST3Gal III; alpha 2,3-ST 3; alpha-2,3-sialyltransferase II; alpha 2,3-sialyltransferase III; Gal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferase; sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase); ST3N; MRT12; SIAT6; ST3GALII; ST3GalIII
• Gene ID: 6487
• mRNA Refseq: NM_001270459
• Protein Refseq: NP_001257388
• MIM: 606494
• UniProt ID: Q11203

Reviews

05/05/2022

The catalytic activity of this protein is very excellent, and it can be widely used in various chemical reactions, so its application prospects are very broad.

04/20/2022

Due to stability of ST3GAL3 is very strong, maintaining its structural and functional stability even after extensive use, which shows its excellent quality and reliability.

08/03/2020

ST3GAL3 are very safe and can be used with confidence.

Q&As

What is the role of ST3GAL3 protein in nervous system development?

ST3GAL3 proteins play an important role in the development of the nervous system, it is involved in the process of neuronal formation and synaptic connections, and is essential for the normal development and maintenance of the nervous system.

Are there multiple subtypes of ST3GAL3 genes?

Yes, there are multiple subtypes of ST3GAL3 genes, which may have different functional and regulatory properties when encoding ST3GAL3 proteins.

What is the function of ST3GAL3 protein?

The protein is a glycosyltransferase that participates in a glycosylation reaction that combines acetylneuraminic acid and sialic acid to form sialic acid-α-2,3-acetylneuraminominia. This glycosylation modification plays an important role in cell recognition and signaling.

What diseases are ST3GAL3 proteins associated with?

ST3GAL3 protein has been linked to a variety of neurological-related diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and others. Abnormal expression or functional deficits may cause developmental and functional disorders of the nervous system.

Are there interactions between ST3GAL3 proteins and other molecules in the nervous system?

There may be interactions between ST3GAL3 proteins and other molecules in the nervous system, such as with neuronal surface receptors or cell adhesion molecules, but the specific interaction network needs to be studied in depth.

What are the molecular mechanisms of ST3GAL3 proteins in neuronal development?

ST3GAL3 proteins are involved in neuronal development by regulating signaling pathways related to cell adhesion, migration and synaptic formation, and the specific mechanism needs further study.