Recombinant Human ST3GAL3 293 Cell Lysate

• Cat.No.: ST3GAL3-1441HCL

Specification

• Description: Antigen standard for ST3 beta-galactoside alpha-2,3-sialyltransferase 3 (ST3GAL3), transcript variant 2 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
• Source: HEK 293 cells
• Species: Human
• Components: This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
• Size: 0.1 mg
• Storage Instruction: Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
• Applications: ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
• Tag: Non

Gene Information

• Gene Name: ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Homo sapiens ]
• Official Symbol: ST3GAL3
• Synonyms: ST3GAL3; ST3 beta-galactoside alpha-2,3-sialyltransferase 3; sialyltransferase 6 (N acetyllacosaminide alpha 2,3 sialyltransferase) , SIAT6; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; ST3Gal III; alpha 2,3-ST 3; alpha-2,3-sialyltransferase II; alpha 2,3-sialyltransferase III; Gal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferase; sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase); ST3N; MRT12; SIAT6; ST3GALII; ST3GalIII
• Gene ID: 6487
• mRNA Refseq: NM_006279
• Protein Refseq: NP_006270
• MIM: 606494
• UniProt ID: Q11203
• Chromosome Location: 1p34.1
• Pathway: Glycosaminoglycan biosynthesis - keratan sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - keratan sulfate, conserved biosystem; Glycosphingolipid biosynthesis - lacto and neolacto series, organism-specific biosystem; Glycosphingolipid biosynthesis - lacto and neolacto series, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; O-linked glycosylation of mucins, organism-specific biosystem

Reviews

05/05/2022

The catalytic activity of this protein is very excellent, and it can be widely used in various chemical reactions, so its application prospects are very broad.

04/20/2022

Due to stability of ST3GAL3 is very strong, maintaining its structural and functional stability even after extensive use, which shows its excellent quality and reliability.

08/03/2020

ST3GAL3 are very safe and can be used with confidence.

Q&As

What is the role of ST3GAL3 protein in nervous system development?

ST3GAL3 proteins play an important role in the development of the nervous system, it is involved in the process of neuronal formation and synaptic connections, and is essential for the normal development and maintenance of the nervous system.

Are there multiple subtypes of ST3GAL3 genes?

Yes, there are multiple subtypes of ST3GAL3 genes, which may have different functional and regulatory properties when encoding ST3GAL3 proteins.

What is the function of ST3GAL3 protein?

The protein is a glycosyltransferase that participates in a glycosylation reaction that combines acetylneuraminic acid and sialic acid to form sialic acid-α-2,3-acetylneuraminominia. This glycosylation modification plays an important role in cell recognition and signaling.

What diseases are ST3GAL3 proteins associated with?

ST3GAL3 protein has been linked to a variety of neurological-related diseases, including Parkinson's disease, Alzheimer's disease, Huntington's disease, and others. Abnormal expression or functional deficits may cause developmental and functional disorders of the nervous system.

Are there interactions between ST3GAL3 proteins and other molecules in the nervous system?

There may be interactions between ST3GAL3 proteins and other molecules in the nervous system, such as with neuronal surface receptors or cell adhesion molecules, but the specific interaction network needs to be studied in depth.

What are the molecular mechanisms of ST3GAL3 proteins in neuronal development?

ST3GAL3 proteins are involved in neuronal development by regulating signaling pathways related to cell adhesion, migration and synaptic formation, and the specific mechanism needs further study.