Recombinant Human SIX Homeobox 1, His-tagged

• Cat.No.: SIX1-7160H
• Product Overview: Recombinant human SIX1 protein, fused to His-tag at N-terminus, was expressed in E. coli. MW: 34.7 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-284aa
• Description: SIX1, also known as homeobox protein SIX1, is a member of the SIX gene family. It encodes protein that is characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein-protein interactions. It has been shown to play roles in vertebrate and insect development or has been implicated in maintenance of the differentiated state of tissues.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 2M Urea.
• Molecular Mass: 34.7 kDa(308aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMSMLPS FGFTQEQVAC VCEVLQQGGN LERLGRFLWS LPACDHLHKN ESVLKAKAVV AFHRGNFREL YKILESHQFS PHNHPKLQQL WLKAHYVEAE KLRGRPLGAV GKYRVRRKFP LPRTIWDGEE TSYCFKEKSR GVLREWYAHN PYPSPREKRE LAEATGLTTT QVSNWFKNRR QRDRAAEAKE RENTENNNSS SNKQNQLSPL EGGKPLMSSS EEEFSPPQSP DQNSVLLLQG NMGHARSSNY SLPGLTASQP SHGLQTHQHQ LQDSLLGPLT SSLVDLGS
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 1.0 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SIX1 SIX homeobox 1 [ Homo sapiens ]
• Official Symbol: SIX1
• Synonyms: SIX1; SIX homeobox 1; deafness, autosomal dominant 23 , DFNA23, sine oculis homeobox (Drosophila) homolog 1 , sine oculis homeobox homolog 1 (Drosophila); homeobox protein SIX1; sine oculis homeobox homolog 1; BOS3; TIP39; DFNA23
• Gene ID: 6495
• mRNA Refseq: NM_005982
• Protein Refseq: NP_005973
• MIM: 601205
• UniProt ID: Q15475
• Chromosome Location: 14q23.1
• Pathway: Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem
• Function: DNA binding; chromatin binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding