SIX1
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Official Full Name
SIX homeobox 1 -
Overview
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila sine oculis gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). -
Synonyms
SIX1;SIX homeobox 1;deafness, autosomal dominant 23 , DFNA23, sine oculis homeobox (Drosophila) homolog 1 , sine oculis homeobox homolog 1 (Drosophila);homeobox protein SIX1;BOS3;DFNA23;OTTHUMP00000179042;Sine oculis homeobox homolog 1;SIX1_HUMAN;TIP39
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SIX1-30869TH | Recombinant Human SIX1 | Wheat Germ | Human | Non | 284 amino acids |
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| SIX1-3477C | Recombinant Chicken SIX1 | Mammalian Cells | Chicken | His |
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| SIX1-7160H | Recombinant Human SIX Homeobox 1, His-tagged | E.coli | Human | His | 1-284aa |
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| SIX1-1825HCL | Recombinant Human SIX1 293 Cell Lysate | HEK293 | Human | Non |
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| SIX1-476HF | Recombinant Full Length Human SIX1 Protein | In Vitro Cell Free System | Human | Full L. 284 amino acids |
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Involved Pathway
SIX1 involved in several pathways and played different roles in them. We selected most pathways SIX1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | TRP53,TFE3,ETV6,SPI1,IL3,TCF3,MLLT3,PPARG,PLAT,ARNT2 |
Protein Function
SIX1 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIX1 itself. We selected most functions SIX1 had, and list some proteins which have the same functions with SIX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TFCP2,PSG1,PPP2R5D,KRT25,CDC6,RPLP0,DBF4B,AURKB,MPP6,PHLDA1 |
| chromatin binding | RNF2,PRKCBP1L,CAPNS2,NPM2,ATF2,CBFA2T3,MLH3,POLG,KLF6A,GATA6 |
| sequence-specific DNA binding | ZSCAN23,FOXC1A,HOXB2A,TEFA,CREB3L1,RXRAA,CHES1,CUX1,FOXO6,TBX3 |
| DNA binding | H1M,PHC2B,JUNBA,PHC1,SIX6,UNCX4.1,DLX5A,FOXG1,TAF4B,FOXF2A |
| transcription regulatory region DNA binding | NCOR1,SALL2,ZNF821,MZF1,NKX3-1,ZFP335,SOX5,CBX4,HNRNPL,PROX1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | IFI16,NKX6-1,GRHL1,ALS2CR8,ARID3B,RBPJ,YBX1,ETV6,NFIC,ELK1 |
| transcription factor activity, sequence-specific DNA binding | ZNF133,ZNF311,GM239,ZXDC,RFXAP,BHLHE40,NKX2-5,CIR1,ZNF302,ZNF192 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TFAM,ELF1,PLSCR1,POU1F1,KLF4,ETV6,SMAD2,FOXL2,PLAG1,CREB1 |
Interacting Protein
SIX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIX1.
AES;MDFI;EYA2;VTN;CCDC85B
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References
- Tan, WJ; Thike, AA; et al. Immunohistochemical expression of homeoproteins Six1 and Pax3 in breast phyllodes tumours correlates with histological grade and clinical outcome. HISTOPATHOLOGY 64:807-817(2014).
- Qamar, L; Deitsch, E; et al. Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer. GYNECOLOGIC ONCOLOGY 125:451-457(2012).
