Recombinant Human SEMA6D cell lysate

• Cat.No.: SEMA6D-1583HCL

Specification

• Description: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Six transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot
• Tag: Non

Gene Information

• Gene Name: SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [ Homo sapiens ]
• Official Symbol: SEMA6D
• Synonyms: SEMA6D; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; semaphorin-6D; FLJ11598; KIAA1479
• Gene ID: 80031
• mRNA Refseq: NM_001198999
• Protein Refseq: NP_001185928
• MIM: 609295
• UniProt ID: Q8NFY4
• Chromosome Location: 15q21.1
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Other semaphorin interactions, organism-specific biosystem; Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem
• Function: receptor activity