SEMA6D

  • Official Full Name

    sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

  • Overview

    Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.

  • Synonyms

    SEMA6D;sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D;semaphorin-6D;FLJ11598;KIAA1479;Q8NFY4;Semaphorin 6D

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Mammalian cells
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • Fc
  • His
  • Non
  • His&Fc&Avi
  • GST

    Involved Pathway

    SEMA6D involved in several pathways and played different roles in them. We selected most pathways SEMA6D participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA6D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance PTK2,KALRNB,SEMA4D,SCN8A,DNM1,AP2A1,SPNA1,Plxna2,FRS3,EGF

    Protein Function

    SEMA6D has several biochemical functions, for example, chemorepellent activity,semaphorin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA6D itself. We selected most functions SEMA6D had, and list some proteins which have the same functions with SEMA6D. You can find most of the proteins on our site.

    Function Related Protein
    semaphorin receptor binding SEMA4B,SEMA6B,SEMA3AB,SEMA3H,SEMA4E,SEMA3AA,SH3BGRL3,SEMA6C,SEMA3E,SEMA6A
    chemorepellent activity SEMA6B,SEMA5B,SEMA3G,SEMA3E,SEMA3D,APOA1,SEMA6E,SEMA6C,NRG3,FLRT2

    Interacting Protein

    SEMA6D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA6D here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA6D.

    Resources

    Research Area

    Semaphorins, Plexin Receptors, and Related Molecules

    References

    • Sambo, F; Malovini, A; et al. Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification. DIABETOLOGIA 57:1611-1622(2014).
    • Matsuoka, RL; Sun, LO; et al. Sema6B, Sema6C, and Sema6D Expression and Function during Mammalian Retinal Development. PLOS ONE 8:-(2013).

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