Recombinant Human Renin

Cat.No. : REN-5473H
Product Overview : Recombinantlyproduced in HEK cell culture as untagged native form prorenin and purified byaffinity chromatography.
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Species : Human
Source : HEK293
Tag : Non
Description : REN is aglycosylated aspartic protease that consists of 2 homologous lobes and is theprecursor of renin. Prorenin exhibits a low level of enzymatic activityrelative to renin which is generated from prorenin by proteolytic cleavage ofthe first 43 amino acids at the N-terminus. This so-called prosegment appearsto block the full enzymatic potential of the active site.
Form : Frozen liquid in 10mM Tris Buffer + 0.1 M NaCl, pH 8.0.
Purity : >95% by SDS-PAGEanalysis
MolecularWeight : 43.725 kDa
Endotoxin Level : < 0.1 ng/μg ofprotein
Concentration : 1.0 mg/ml
Storage : Store at -80°C.Stable for 3 years from delivery. Avoid repeated freeze-thaw cycles.
OfficialSymbol : REN
Pathways : ACE InhibitorPathway; Renin-angiotensin system
Gene Name REN renin [ Homo sapiens]
Synonyms REN;renin; HNFJ2; OTTHUMP00000034311; angiotensinogenase; reninprecursor, renal; angiotensin-forming enzyme; EC 3.4.23.15; Renin; Angiotensinogenase
Gene ID 5972
mRNA Refseq NM_000537
Protein Refseq NP_000528
MIM 179820
UniProt ID P00797
Chromosome Location 1q32
Function aspartic-typeendopeptidase activity; insulin-like growth factor receptor binding;peptidase activity; receptor binding

Not For Human Consumption!

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