Active Native Human Renin Antigen

• Cat.No.: REN-388H
• Product Overview: Native Human Renin Antigen was purified from Human Kidney.

Specification

• Species: Human
• Source: Human Kidney
• Tag: Non
• Description: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
• Form: Clear, colorless liquid. Liquid in sodium acetate, EDTA and benzamidine, pH 6.0.
• Bio-activity: Typically >1 U/mL
• Purity: >90% (Electrophoresis)
• Unit Definition: Renin Activity was measured by following the cleavage of the fluorogenic substrate Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg at pH 8.0 and 37C.
• Storage: 2-8 °C
• Concentration: Protein: >0.1 mg protein/mL (Lowry)

Gene Information

• Gene Name: REN renin [ Homo sapiens ]
• Official Symbol: REN
• Synonyms: REN; renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme; HNFJ2; FLJ10761
• Gene ID: 5972
• mRNA Refseq: NM_000537
• Protein Refseq: NP_000528
• MIM: 179820
• UniProt ID: P00797
• Chromosome Location: 1q32
• Pathway: ACE Inhibitor Pathway, organism-specific biosystem; Renin-angiotensin system, organism-specific biosystem; Renin-angiotensin system, conserved biosystem
• Function: aspartic-type endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding