Recombinant Human PNPLA3 protein, His&Myc-tagged

• Cat.No.: PNPLA3-754H
• Product Overview: Recombinant Human PNPLA3 protein(Q9NST1)(63-481aa), fused with N-terminal His tag and C-terminal Myc tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Human
• Tag: His&Myc
• Protein length: 63-481a.a.
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 53.7 kDa
• AASequence: EQTLQVLSDLVRKARSRNIGIFHPS FNLSKFLRQGLCKCLPANVHQLISG KIGISLTRVSDGENVLVSDFRSKDE VVDALVCSCFIPFYSGLIPPSFRGV RYVDGGVSDNVPFIDAKTTITVSPF YGEYDICPKVKSTNFLHVDITKLSL RLCTGNLYLLSRAFVPPDLKVLGEI CLRGYLDAFRFLEEKGICNRPQPGL KSSSEGMDPEVAMPSWANMSLDSSP ESAALAVRLEGDELLDHLRLSILPW DESILDTLSPRLATALSEEMKDKGG YMSKICNLLPIRIMSYVMLPCTLPV ESAIAIVQRLVTWLPDMPDDVLWLQ WVTSQVFTRVLMCLLPASRSQMPVS SQQASPCTPEQDWPCWTPCSPKGCP AETKAEATPRSILRSSLNFFLGNKV PAGAEGLSTFPSFSLEKSL
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: PNPLA3 patatin-like phospholipase domain containing 3 [ Homo sapiens ]
• Official Symbol: PNPLA3
• Synonyms: PNPLA3; patatin-like phospholipase domain containing 3; adiponutrin , ADPN, C22orf20, chromosome 22 open reading frame 20; patatin-like phospholipase domain-containing protein 3; adiponutrin; dJ796I17.1; FLJ22012; iPLA2-epsilon; acylglycerol O-acyltransferase; calcium-independent phospholipase A2-epsilon; ADPN; C22orf20; iPLA(2)epsilon
• Gene ID: 80339
• mRNA Refseq: NM_025225
• Protein Refseq: NP_079501
• MIM: 609567
• UniProt ID: Q9NST1

Reviews

03/21/2022

Manufacturers should ensure the consistency and quality of PNPLA3 protein products.

04/09/2017

The PNPLA3 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

11/02/2016

Its purity, stability, and functionality make it an ideal choice for my research endeavors.

Q&As

Does PNPLA3 play a role in other health conditions beyond liver disease?

PNPLA3 primarily influences lipid metabolism and liver health, but there may be connections with other metabolic disorders.

Can changes in diet and lifestyle help individuals with PNPLA3-related liver conditions?

Yes, dietary and lifestyle modifications, such as weight loss and reduced alcohol consumption, can help manage liver diseases associated with PNPLA3 variants.

How does PNPLA3 affect liver fibrosis progression in NAFLD patients?

PNPLA3 variants may accelerate liver fibrosis in NAFLD, making it a potential marker for disease severity.

Can children inherit PNPLA3 variants from their parents?

Yes, PNPLA3 gene variants can be inherited from parents and can increase the risk of liver diseases in children.

Are there any medications or therapies targeting PNPLA3 for the treatment of liver diseases?

There are no specific drugs targeting PNPLA3, but therapies for liver diseases often take into account a patient's genetic profile, including PNPLA3 variants.