Recombinant Human PDGFB, His-tagged

• Cat.No.: PDGFB-58H
• Product Overview: Recombinant Human Platelet-derived Growth Factor B mature chain produced inE.Coliis a non-glycosylated, polypeptide chain containing 109 amino acids fragment (82-190) and having with an amino-terminal His-tag. PDGF-B is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 82-190 a.a.
• Description: The term 'PDGF' refers to a family of disulphide bond-linked dimeric isoforms that act as autocrine and paracrine growth factors and are produced by a variety of cell types other than platelets. They act as potent mitogens for almost all mesenchymally-derived cells. Aberrant expression is involved in certain cancers, fibroproliferative disorders and atherosclerosis. The protein also contributes to wound healing and neural regeneration. There are four members of the PDGF family-PDGF A, PDGF B, PDGF C and PDGF D. Two distinct types of PDGF-A exist-a short form that is soluble and a long form that is retained by the extracellular matrix.
• Physical Appearance: Sterile Filtered clear solution.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: Platelet-Derived Growth Factor-B is supplied in 1x PBS and 50% glycerol.
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Gene Information

• Gene Name: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) [ Homo sapiens ]
• Synonyms: PDGFB; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); SIS; SSV; PDGF2; c-sis; FLJ12858; PDGFB; PDGF subunit B; Platelet-derived growth factor B chain; Platelet-derived growth factor beta; PDGF-2; Platelet-derived growth factor, beta polypeptide (oncogeneSIS); platelet-derived growth factor 2
• Gene ID: 5155
• mRNA Refseq: NM_002608
• Protein Refseq: NP_002599
• UniProt ID: P01127
• Chromosome Location: 22q12.3-q13.1; 22q13.1
• MIM: 190040
• Pathway: Cytokine-cytokine receptor interaction; Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Prostate cancer; Regulation of actin cytoskeleton; Hemostasis; Signaling by PDGF
• Function: cell surface binding; collagen binding; growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; contributes_to platelet-derived growth factor receptor binding; protein heterodimerization activity