Recombinant Human IMPDH2, MYC/DDK-tagged
Cat.No. : | IMPDH2-1276H |
Product Overview : | Recombinant Human IMPDH2, fused with C-terminal MYC/DDK, was expressed in HEK293 cells. |
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Species : | Human |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
Molecular Mass : | 55.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name | IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 [ Homo sapiens (human) ] |
Official Symbol | IMPDH2 |
Synonyms | IMPDH2; IMPDH 2; IMPD2; IMPD 2; IMP (inosine 5"-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMPDH-II; IMP oxireductase 2; inosine 5" phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; IMP dehydrogenase 2; inosine-5"-monophosphate dehydrogenase 2; IMP dehydrogenase 2; EC 1.1.1.205; OTTHUMP00000210556 |
Gene ID | 3615 |
mRNA Refseq | NM_000884 |
Protein Refseq | NP_000875 |
MIM | 146691 |
UniProt ID | P12268 |
Chromosome Location | 3p21.2 |
Pathway | Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism; Purine ribonucleoside monophosphate biosynthesis |
Function | IMP dehydrogenase activity; metal ion binding; nucleotide binding; oxidoreductase activity; protein binding |
◆ Recombinant Proteins | ||
IMPDH2-1260HFL | Recombinant Full Length Human IMPDH2, Flag-tagged | +Inquiry |
IMPDH2-8199M | Recombinant Mouse IMPDH2 Protein | +Inquiry |
IMPDH2-1274H | Recombinant Human IMP (Inosine 5'-Monophosphate) Dehydrogenase 2, His-tagged | +Inquiry |
IMPDH2-01H | Active Recombinant Human IMPDH2 Protein, His tagged | +Inquiry |
IMPDH2-1276H | Recombinant Human IMPDH2, MYC/DDK-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
IMPDH2-5210HCL | Recombinant Human IMPDH2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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