Active Recombinant Human IMPDH2
Cat.No. : | IMPDH2-83H |
Product Overview : | Recombinant Human IMPDH2 has been cloned by RT-PCR amplification of mRNA extracted from human hepatoma cells (sequence confirmed) and expressed in E.coli. Purified IMPDH 2 is an active enzyme characterized for its affinity for inosine 5'-monophosphate and NAD substrates, and its sensitivity to enzyme inhibitors such as mycophenolic acid and ribavirine-monophosphate. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Description : | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
Bio-activity : | ≥ 0.050 unit/mg protein. |
Unit Definition : | One unit of IMPDH Type II catalyzes the oxydation of 1 µmole of IMP to XMP per minute at pH 8.8 at 37 °C |
Gene Name | IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 [ Homo sapiens (human) ] |
Official Symbol | IMPDH2 |
Synonyms | IMPDH2; IMP (inosine 5"-monophosphate) dehydrogenase 2; IMPD2; IMPDH-II; EC 1.1.1.205; Inosine-5"-monophosphate dehydrogenase 2; IMP dehydrogenase 2 |
Gene ID | 3615 |
mRNA Refseq | NM_000884 |
Protein Refseq | NP_000875 |
MIM | 146691 |
UniProt ID | P12268 |
Chromosome Location | 3p21.2 |
Pathway | Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism; Metabolism of nucleotides |
Function | IMP dehydrogenase activity; metal ion binding; oxidoreductase activity; protein binding |
◆ Recombinant Proteins | ||
IMPDH2-5866HF | Recombinant Full Length Human IMPDH2 Protein, GST-tagged | +Inquiry |
IMPDH2-28270TH | Recombinant Human IMPDH2, His-tagged | +Inquiry |
IMPDH2-11510Z | Recombinant Zebrafish IMPDH2 | +Inquiry |
IMPDH2-1260HFL | Recombinant Full Length Human IMPDH2, Flag-tagged | +Inquiry |
Impdh2-3532M | Recombinant Mouse Impdh2 Protein, Myc/DDK-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
IMPDH2-5210HCL | Recombinant Human IMPDH2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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